Results 1 to 10 of about 54,850 (202)

Psychedelics promote plasticity by directly binding to BDNF receptor TrkB

Nature Neuroscience, 2023
Psychedelics produce fast and persistent antidepressant effects and induce neuroplasticity resembling the effects of clinically approved antidepressants.
Mykhailo Girych, Cecilia Anna Brunello, Vera Kovaleva   +2 more
exaly   +2 more sources

TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice

Nature Communications, 2022
Premature ovarian failure (POF) is a leading cause of women’s infertility without effective treatment. Here we show that intravenous injection of Ab4B19, an agonistic antibody for the BDNF receptor TrkB, penetrates into ovarian follicles, activates TrkB ...
Xunsi Qin, Yue Zhao, Chenghong Yin
exaly   +2 more sources

Serotonin Receptor 5-HT_2A Regulates TrkB Receptor Function in Heteroreceptor Complexes

Cells, 2022
Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and are implicated in numerous neuronal disorders.
Tatiana Ilchibaeva, Anton Tsybko, Andre Zeug, Franziska E. Müller, Daria Guseva, Stephan Bischoff, Evgeni Ponimaskin, Vladimir Naumenko   +7 more
doaj   +2 more sources

The Role of Altered BDNF/TrkB Signaling in Amyotrophic Lateral Sclerosis

Frontiers in Cellular Neuroscience, 2019
Brain derived neurotrophic factor (BDNF) is well recognized for its neuroprotective functions, via activation of its high affinity receptor, tropomysin related kinase B (TrkB).
Jonu Pradhan, Peter G. Noakes, Peter G. Noakes, Mark C. Bellingham   +3 more
doaj   +2 more sources

Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists

Pharmaceuticals, 2021
TrkB is a tyrosine kinase receptor that is activated upon binding to brain-derived neurotrophic factor (BDNF). To date, the search for low-molecular-weight molecules mimicking BDNF’s action has been unsuccessful. Several molecules exerting antidepressive
Piotr Pankiewicz, Marcin Szybiński, Katarzyna Kisielewska, Filip Gołębiowski, Patryk Krzemiński, Izabela Rutkowska-Włodarczyk, Rafał Moszczyński-Pętkowski, Lidia Gurba-Bryśkiewicz, Monika Delis, Krzysztof Mulewski, Damian Smuga, Jakub Dominowski, Artur Janusz, Michał Górka, Krzysztof Abramski, Agnieszka Napiórkowska, Marcin Nowotny, Krzysztof Dubiel, Katarzyna Kalita, Maciej Wieczorek, Jerzy Pieczykolan, Mikołaj Matłoka   +21 more
doaj   +2 more sources

Regulation of NTRK2 alternative splicing by PRPF40B controls neural differentiation and synaptic plasticity [PDF]

Cell Death and Disease
BDNF signaling through its receptor TRKB plays a critical role in brain development, neuroplasticity, and homeostasis. Alternative splicing of the TRKB gene, NTRK2, generates either the full-length receptor (TRKB-FL) or a truncated isoform (TRKB-T1) that
María Duarte-Ruiz, Adela Moreno-Castillo, Younes El Yousfi, Cristina Moreno-Castro, Noelia Martínez-Martínez, Sandra Jiménez-Lozano, Marion Kennel, Candela Ruiz-Rodríguez, Alonso Rodríguez-Caparrós, Jennifer López-Ros, Pierre de la Grange, Cristina Hernández-Munain, Carlos Suñé   +12 more
doaj   +2 more sources

Retrograde transport of TrkB-containing autophagosomes via the adaptor AP-2 mediates neuronal complexity and prevents neurodegeneration

Nature Communications, 2017
Autophagosomes primarily mediate turnover of cytoplasmic proteins or organelles to provide nutrients and eliminate damaged proteins. In neurons, autophagosomes form in distal axons and are trafficked retrogradely to fuse with lysosomes in the soma ...
Natalia L Kononenko, Marijn Kuijpers, Dmytro Puchkov   +2 more
exaly   +2 more sources

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals

Nature Communications, 2019
Amphisomes are organelles of the autophagy pathway that result from the fusion of autophagosomes with late endosomes. While biogenesis of autophagosomes and late endosomes occurs continuously at axon terminals, non-degradative roles of autophagy at ...
Maria Andres-Alonso, Guilherme M Gomes, Pingan Yuanxiang   +2 more
exaly   +2 more sources

Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons

Nature Communications, 2018
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch
Francisco J Taberner, Linda Nocchi, Carla Portulano   +2 more
exaly   +2 more sources

STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

Nature Cell Biology, 2020
Andrew J Paris, Katharina E Hayer, Daphne C Avgousti   +2 more
exaly   +2 more sources