Results 101 to 110 of about 54,934 (280)

Dimeric dipeptide mimetics of BDNF loop 4 are potential antidepressants with novel mechanisms of action

Фармакокинетика и Фармакодинамика
This review covers original research focused on the design, synthesis, and pharmacological evaluation of an innovative dimeric dipeptide mimetic of brain-derived neurotrophic factor (BDNF) loop 4 bis-(N-monosuccinyl-L-seryl-L-lysine) hexamethylenediamide
T. A. Gudasheva, P. Yu. Povarnina, A. V. Tarasyuk, V. P. Zherdev, A. D. Durnev   +4 more
doaj   +1 more source

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements [PDF]

, 2001
Many neurons die as the normal brain develops. How this is regulated and whether the mechanism involves neurotrophic molecules from target cells are unknown.
Asavaritikrai, P, Lotto, RB, Price, DJ, Vali, L   +3 more
core   +1 more source

Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities

Scientific Reports, 2020
Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity.
T. Sonoyama, L. Stadler, Mingyan Zhu, J. Keogh, E. Henning, F. Hisama, P. Kirwan, Magdalena Jura, B. Blaszczyk, David C. DeWitt, B. Brouwers, M. Hyvönen, I. Barroso, F. Merkle, S. Appleyard, G. Wayman, S. Farooqi   +16 more
semanticscholar   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Regulation of a TrkB Alternative Transcript by microRNAs

Dementia and Geriatric Cognitive Disorders Extra, 2014
Background/Aims: Tropomyosin-related kinase B receptor (TrkB)-mediated signaling is vital for neuronal differentiation, survival, plasticity, and cognition.
Jenny Wong
doaj   +1 more source

Nerve growth factor, brain-derived neurotrophic factor, and the chronobiology of mood: a new insight into the "neurotrophic hypothesis" [PDF]

, 2015
The light information pathways and their relationship with the body rhythms have generated a new insight into the neurobiology and the neurobehavioral sciences, as well as into the clinical approaches to human diseases associated with disruption of ...
IANNITELLI, ANGELA, Quartini, Adele, Tirassa, Paola   +2 more
core   +2 more sources

2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway

International Journal of Molecular Sciences, 2020
Depression is a serious medical illness that is one of the most prevalent psychiatric disorders. Corticosterone (CORT) increases depression-like behavior, with some effects on anxiety-like behavior.
Young-Ju Lee, Hye Ryeong Kim, Chang Youn Lee, S. Hyun, Moon Yi Ko, Byoung-Seok Lee, D. Hwang, Minhan Ka   +7 more
semanticscholar   +1 more source

Harnessing Piezoelectric Biomaterials for Pathogenic Eradication and Tissue Regeneration

Exploration, EarlyView.
This review highlights recent advances in piezoelectric biomaterials for antibacterial therapy and tissue regeneration, discussing material classifications, catalytic mechanisms, property enhancements, biomedical applications, and future challenges in clinical translation.
Wenxuan Mao, Xiaoye Li, Ao He, Meng Ding, Yu Zhang, Zhuo Dai, Qiang Li, Weijun Xiu, Yanling Hu, Yongbin Mou, Dongliang Yang, Heng Dong   +11 more
wiley   +1 more source

Effects of Exercise Preconditioning on Neurotrophin-4 and Tropomyosin Receptor Kinase B Expression in the Hippocampal CA1 Region Following Transient Global Cerebral Ischemia/Reperfusion in Wistar Rats

Medical Laboratory Journal, 2019
Background and Objectives: Cerebral ischemia causes irreversible structural and functional damage in certain areas of the brain, especially in the hippocampus.
Mohtaram Yazdanian, Mahtab Moazami, Mohammad Shabani, Sadegh Cheragh Birjandi   +3 more
doaj  

Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy. [PDF]

, 2012
Protein synthesis is highly regulated throughout nervous system development, plasticity and regeneration. However, tracking the distributions of specific new protein species has not been possible in living neurons or at the ultrastructural level ...
Butko, Margaret T, Ellisman, Mark H, Geng, Yang, Jeon, Noo Li, Kim, Hyung Joon, Lin, Michael Z, Mackey, Mason R, Shu, Xiaokun, Tsien, Roger Y, Yang, Jin   +9 more
core   +1 more source