Results 111 to 120 of about 54,934 (280)
Experimental biology and medicine, 2019 This study aimed to investigate the effect of Angelica sinensis polysaccharides (ASP) on Alzheimer’s disease (AD) and its underlying mechanisms. In our study, we build the AD model by injecting Aβ25–35.
Qian Du, Xiaoyu Zhu, Jieru Si
semanticscholar +1 more source
Cell and Tissue Research, 2020 Neurotrophin signaling via receptor tyrosine kinases is essential for the development and function of the nervous system in vertebrates. TrkB activation and signaling show substantial differences to other receptor tyrosine kinases of the Trk family that ...
Thomas Andreska +2 more
semanticscholar +1 more source
Ibrain, EarlyView.In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard +2 more
wiley +1 more source
Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library [PDF]
, 2018 The diverse physiological roles of the neurotrophin family have long prompted exploration of their potential as therapeutic agents for nerve injury and neurodegenerative diseases.
Allen, Nicholas D. +14 more
core +2 more sources
International Journal of Molecular Sciences, 2020 Intravitreal delivery of brain-derived neurotrophic factor (BDNF) by injection of recombinant protein or by gene therapy can alleviate retinal ganglion cell (RGC) loss after optic nerve injury (ONI) or laser-induced ocular hypertension (OHT).
Anna Wójcik-Gryciuk +5 more
semanticscholar +1 more source
Mechanism of TrkB-Mediated Hippocampal Long-Term Potentiation [PDF]
Neuron, 2002 The TrkB receptor tyrosine kinase and its ligand, BDNF, have an essential role in certain forms of synaptic plasticity. However, the downstream pathways required to mediate these functions are unknown. We have studied mice with a targeted mutation in either the Shc or the phospholipase Cgamma (PLCgamma) docking sites of TrkB (trkB(SHC/SHC) and trkB(PLC/
Minichiello Liliana +5 more
openaire +5 more sources
Medicine Advances, EarlyView.Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting +1 more
wiley +1 more source
The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats. [PDF]
PLoS ONE, 2014 Cyclin-dependent kinase 5 (Cdk5) has been shown to play an important role in mediating inflammation-induced heat hyperalgesia. However, the underlying mechanism remains unclear.
Hong-Hai Zhang +9 more
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases. [PDF]
FEBS Open BioTropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Enkavi G.
europepmc +2 more sources
JIP3 Mediates TrkB Axonal Anterograde Transport and Enhances BDNF Signaling by Directly Bridging TrkB with Kinesin-1 [PDF]
Journal of Neuroscience, 2011 Brain-derived neurotrophic factor (BDNF), secreted from target tissues, binds and activates TrkB receptors, located on axonal terminals of the innervating neurons, and thereby initiates retrograde signaling. Long-range anterograde transport of TrkB in axons and dendrites requires kinesin-mediated transport.
Shu-Hong, Huang +8 more
openaire +2 more sources