Results 151 to 160 of about 54,934 (280)
Obesity Reviews, EarlyView.ABSTRACT Obesity is one of the most prevalent health problems worldwide, and global obesity rates continue to rise. Consequently, rates of obesity in expecting mothers and fathers have also increased. The Developmental Origins of Health and Disease (DOHaD) hypothesis postulates that early‐life exposure to adverse environmental conditions contributes to
Hannah Chadwick +3 more
wiley +1 more source
Lifelong nutritional omega-3 deficiency evokes depressive-like state through soluble beta amyloid [PDF]
, 2016 Recent evidence pointed out that the prevalence of depression has reached epidemic proportions in last decades. This increase has been linked to many environmental factors, among these the influence of dietary factors has gained great attention.
BOVE, MARIA +6 more
core +1 more source
Estradiol induces BDNF/TrkB signaling in triple-negative breast cancer to promote brain metastases
Oncogene, 2019 Breast cancer brain metastases (BM) affect younger women disproportionally, including those lacking estrogen receptor (ER), progesterone receptor, and HER2 (known as triple-negative breast cancer; TNBC). Previous studies in preclinical models showed that
Maria J. Contreras-Zárate +7 more
semanticscholar +1 more source
Orthodontics &Craniofacial Research, EarlyView.ABSTRACT Objective Sympathetic‐sensory coupling is increasingly implicated in joint homeostasis and disease. Towards the long‐term goal of deciphering its role in temporomandibular disorders (TMDs), we characterised the spatial relationships of sympathetic and sensory nerves and their receptors in the mouse temporomandibular joint (TMJ) and trigeminal ...
Qianlin Ye +4 more
wiley +1 more source
Breast Cancer Research, 2017 Background Patients with primary breast cancer that is positive for human epidermal growth factor receptor 2 (Her2+) have a high risk of developing metastases in the brain.
Cecilia Choy +7 more
doaj +1 more source
The truncated TrkB receptor influences mammalian sleep
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2015 Brain-derived neurotrophic factor (BDNF) is a neurotrophin hypothesized to play an important role in mammalian sleep expression and regulation. In order to investigate the role of the truncated receptor for BDNF, TrkB.T1, in mammalian sleep, we examined sleep architecture and sleep regulation in adult mice constitutively lacking this receptor. We find
Adam J, Watson +3 more
openaire +3 more sources
The central benefit of physiologically induced ketogenic states
The Journal of Physiology, EarlyView.Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco +6 more
wiley +1 more source
My career in molecular biology [PDF]
, 2002 Norman Davidson's training as a physical chemist led him to make key early contributions to the chemistry of DNA. He described the details of DNA denaturation and renaturation, concepts that still form the basis for understanding hybridization.
Davidson, Norman
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A schematic diagram outlining the concept of enviromimetics, and the subclasses of exercise mimetics, epimimetics and cognitomimetics. The rationale is that environmental stimulation and lifestyle factors, including physical activity and cognitive stimulation, have shown beneficial effects across a range of human conditions ...
Anthony J. Hannan
wiley +1 more source
PLoS ONE, 2010 In the last decades, few mechanistically novel therapeutic agents have been developed to treat mental and neurodegenerative disorders. Numerous studies suggest that targeting BDNF and its TrkB receptor could be a promising therapeutic strategy for the ...
Maxime Cazorla +6 more
doaj +1 more source