Results 171 to 180 of about 54,934 (280)
副腎髄質におけるP2X4受容体を介したBrain-derived neurotrophic factorの発現とTrkBの役割 [PDF]
, 2016 副腎髄質におけるP2X4受容体を介した脳由来神経栄養因子(BDNF)の発現とTrkBの役割について検討した。ラット副腎髄質由来クロマフィン細胞(PC12)を用いた。抗TrkB(clone 47/TrkB)がTrkB作用抗体として作用し、60分ストレス条件下でのラット副腎髄質のTrkBがTrkB作用抗体によりカテコールアミン放出を誘起した。BDNF発現は、ラットの副腎髄質で確認し、BDNFは副腎髄質で自己分泌機能をもつ可能性が示唆された。副腎髄質では急性ストレス条件下でBDNF ...
杉山 弘起
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Advanced Science, Volume 13, Issue 7, 3 February 2026.Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang +7 more
wiley +1 more source
International Journal of Eating Disorders, Volume 59, Issue 2, Page 260-275, February 2026.ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with brain volume reduction, glial cell loss, microbiome alterations, and dysregulated pro‐inflammatory mechanisms. However, the underlying cellular mechanisms remain inadequately elucidated, and interventions addressing these alterations are lacking.
A. C. Thelen +17 more
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Cancer Management and ResearchHu X, Zou W, Liu D, Qin G, Jiang L. Cancer Manag Res. 2020;12:6865–6875. We, the Editor and Publisher of the journal Cancer Management and Research have retracted the published article.
Hu X, Zou W, Liu D, Qin G, Jiang L
doaj
Genetic Dissection of BDNF and TrkB Expression in Glial Cells
BiomoleculesThe brain-derived neurotrophic factor (BDNF) and its high-affinity receptor tropomyosin-related kinase receptor B (TrkB) are widely expressed in the central nervous system. It is well documented that neurons express BDNF and full-length TrkB (TrkB.FL) as
Changran Niu +5 more
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Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation
Food Science &Nutrition, Volume 14, Issue 2, February 2026.Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid +7 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
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Neurotrophins and neuronal plasticity in the action of antidepressants and morphine [PDF]
, 2007 Neuronal plasticity is a well characterized phenomenon in the developing and adult brain. It refers to capasity of a single neuron to modify morphology, synaptic connections and activity.
Sairanen, Mikko
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Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
BDNF/TrkB Signaling and Epileptogenesis
Abstract The epilepsies are one of the most common neurologic disorders with a diversity of etiologies. Despite tremendous advances in both medical and surgical therapies, availability of preventive and disease-modifying therapies is an important unmet medical need.
Stephen C. Harward +2 more
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