Results 11 to 20 of about 54,934 (280)

Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling. [PDF]

PLoS ONE, 2016
Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission.
Andres Stucky, Kalindi P Bakshi, Eitan Friedman, Hoau-Yan Wang   +3 more
doaj   +4 more sources

Taste neurons consist of both a large TrkB-receptor-dependent and a small TrkB-receptor-independent subpopulation. [PDF]

PLoS ONE, 2013
Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) are two neurotrophins that play distinct roles in geniculate (taste) neuron survival, target innervation, and taste bud formation.
Da Fei, Robin F Krimm
doaj   +4 more sources

Effect of vitamin D supplementation on CREB-TrkB-BDNF pathway in the hippocampus of diabetic rats [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): Cyclic AMP (adenosine monophosphate) response element-binding protein (CREB) and Brain-derived neurotrophic factor (BDNF) are reported to broadly involve in learning capacity and memory.
Hoda Nadimi, Abolghassem Djazayery, Mohammad Hassan Javanbakht, Ahmadreza Dehpour, Ehsan Ghaedi, Hoda Derakhshanian, Hamed Mohammadi, Seyedeh Neda Mousavi, Mahmoud Djalali   +8 more
doaj   +1 more source

Study of the interaction of the GSB-106 BDNF neurotrophin dipeptide mimetic with the TrkB tyrosine kinase receptor using surface plasmon resonance technology

Фармакокинетика и Фармакодинамика, 2023
The interaction of the neurotrophin BDNF dipeptide mimetic, compound GSB-106, with the tyrosine kinase TrkB receptor specific for the fullsized neurotrophin was studied using surface plasmon resonance.
A. V. Tarasiuk, Y. V. Mezentsev, O. V. Gnedenko, P. Yu. Povarnina, A. S. Ivanov   +4 more
doaj   +1 more source

A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment

Biomolecules & Therapeutics, 2023
Alzheimer’s disease (AD) is a neurodegenerative disease with progressive memory loss and the cognitive decline. AD is mainly caused by abnormal accumulation of misfolded amyloid β (Aβ), which leads to neurodegeneration via a number of possible mechanisms
Ya-Jen Chiu, Yu-Shan Teng, C. Chen, Ying-Chieh Sun, H. Hsieh-Li, Kuo-Hsuan Chang, G. Lee-Chen   +6 more
semanticscholar   +1 more source

BIOINFORMATICS STUDY OF 7,8-DIHYDROXYFLAVONE AS A NEUROPROTECTIVE AGENT IN ISCHEMIC STROKE VIA TRKB REGULATION AND GLUTAMINASE INHIBITION

Malang Neurology Journal, 2023
Background: Stroke, particularly ischemic stroke, is one of the leading causes of death worldwide. Ischemic stroke causes a failure of oxidative phosphorylation and ATP synthesis, resulting in high levels of reactive oxygen species (ROS ...
Rislan Faiz Muhammad, Basya Adnani, Safira Dita Arviana, Aldita Husna Violita, Husnul Khotimah, Shahdevi Nandar Kurniawan, Mokhamad Fahmi Rizki Syaban, Yuyun Yueniwati Prabowowati Wadjib, Masruroh Rahayu   +8 more
doaj   +1 more source

TrkB-Targeted Therapy for Mucoepidermoid Carcinoma [PDF]

Biomedicines, 2020
The brain-derived neurotrophic factor (BDNF)/tyrosine receptor kinase B (TrkB) pathway was previously associated with key oncogenic outcomes in a number of adenocarcinomas. The aim of our study was to determine the role of this pathway in mucoepidermoid carcinoma (MEC).
Vivian P. Wagner, Manoela D. Martins, Esra Amoura, Virgilio G. Zanella, Rafael Roesler, Caroline B. de Farias, Colin D. Bingle, Pablo A. Vargas, Lynne Bingle   +8 more
openaire   +5 more sources

BDNF/TrkB signaling endosomes in axons coordinate CREB/mTOR activation and protein synthesis in the cell body to induce dendritic growth in cortical neurons

bioRxiv, 2022
Brain-derived neurotrophic factor (BDNF) and its receptors tyrosine kinase receptor B (TrkB) and the p75 neurotrophin receptor (p75) are the primary regulators of dendritic growth in the central nervous system (CNS).
G. Moya-Alvarado, Miguel V. Guerra, Chengbiao Wu, W. Mobley, E. Perlson, F. Bronfman   +5 more
semanticscholar   +1 more source

TrkB Truncated Isoform Receptors as Transducers and Determinants of BDNF Functions

Frontiers in Neuroscience, 2022
Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of secreted growth factors and binds with high affinity to the TrkB tyrosine kinase receptors.
L. Tessarollo, S. Yanpallewar
semanticscholar   +1 more source

BDNF receptor TrkB as the mediator of the antidepressant drug action

Frontiers in Molecular Neuroscience, 2022
Brain-derived neurotrophic factor (BDNF) signaling through its receptor TrkB has for a long time been recognized as a critical mediator of the antidepressant drug action, but BDNF signaling has been considered to be activated indirectly through the ...
P. Casarotto, J. Umemori, E. Castrén
semanticscholar   +1 more source