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Novel and emerging anesthetic drugs for the treatments of major depression: a comprehensive review of efficacy, mechanism, and outlook. [PDF]

Front Psychiatry
Li C, Wang Z, Ye X, Lv J, Chen F, Zhang Y, Liu J, Li X, Duan J, Wang Y, Wang B, Tang W, Zhang J, Teng Y.   +13 more
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Optical Activation of TrkB Signaling

Journal of Molecular Biology, 2020
Brain-derived neurotrophic factor, via activation of tropomyosin receptor kinase B (TrkB), plays a critical role in neuronal proliferation, differentiation, survival, and death. Dysregulation of TrkB signaling is implicated in neurodegenerative disorders and cancers.
Peiyuan, Huang, Aofei, Liu, Yutong, Song, Jen M, Hope, Bianxiao, Cui, Liting, Duan   +5 more
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Evidence that truncated TrkB isoform, TrkB-Shc can regulate phosphorylated TrkB protein levels

Biochemical and Biophysical Research Communications, 2012
Tropomyosin receptor kinase B (TrkB) is best known as the receptor for brain-derived neurotrophic factor (BDNF). In humans, three major isoforms of TrkB, the full-length receptor (TrkB-TK+) and two C-terminal truncated receptors (TrkB-TK- and TrkB-Shc) are expressed in various tissues.
Garner, Brett, Wong, Jenny
openaire   +3 more sources

Connecting reticulophagy and neuronal NTRK2/TrkB signaling

Autophagy, 2023
Tightly regulated cell surface expression of NTRK2/TrkB provides a mechanism for fine-tuning cellular responses to the neurotrophic factor BDNF. Recently, the degradation of NTRK2 by reticulophagy has been identified as a mechanism to limit its availability for trafficking to the cell membrane.
Patrick, Lüningschrör, Michael, Sendtner   +1 more
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TrkB signalling pathways in LTP and learning

Nature Reviews Neuroscience, 2009
Understanding the mechanisms that underlie learning is one of the most fascinating and central aims of neurobiological research. Hippocampal long-term potentiation (LTP) is widely regarded as a prime candidate for the cellular mechanism of learning. The receptor tyrosine kinase TrkB (also known as NTRK2), known primarily for its function during PNS and
Liliana Minichiello
exaly   +3 more sources

TrkB or Not TrkB?

Science Signaling, 2010
Distinct signaling properties of the TrkB neurotrophin receptor explain differential control of developmental cell death in the central and peripheral nervous systems.
openaire   +1 more source

Increased trkB mRNA expression by axotomized motoneurones

NeuroReport, 1994
It has been previously demonstrated that members of the neurotrophin family may prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT-4, increases transiently in spinal motoneurones after axotomy in adult rats.
F, Piehl, J, Frisén, M, Risling, T, Hökfelt, S, Cullheim   +4 more
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