Results 241 to 250 of about 54,934 (280)
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Nitric oxide activation of TrkB through peroxynitrite
NeuroReport, 2000NIH-3T3 cells stably transfected with TrkB, the receptor for brain-derived neurotrophic factor (BDNF), were used to study the effects of NO and peroxynitrite on TrkB. 3-Morpholinosydnonimine (SIN-1), a donor of NO and O2- which immediately react to form peroxynitrite, induced TrkB tyrosine phosphorylation in a dose-dependent relationship from 2 to 40 ...
E C, Yuen, E C, Gunther, M, Bothwell
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Neuroscience, 2021
Exposure to intense or repeated stressors can lead to depression or post-traumatic stress disorder (PTSD). Neurological changes induced by stress include impaired neurotrophin signaling, which is known to influence synaptic integrity and plasticity. The present study used an ex vivo approach to examine the impact of acute or repeated stress on BDNF ...
Siobhan, Robinson +5 more
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Exposure to intense or repeated stressors can lead to depression or post-traumatic stress disorder (PTSD). Neurological changes induced by stress include impaired neurotrophin signaling, which is known to influence synaptic integrity and plasticity. The present study used an ex vivo approach to examine the impact of acute or repeated stress on BDNF ...
Siobhan, Robinson +5 more
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Science's STKE, 2004
In a screen for proteins that would prevent rat intestinal epithelial cell death caused by loss of cell attachment, so-called anoikis, Douma et al. identified the neurotrophin receptor tyrosine kinase TrkB. Further analysis showed that overexpression of TrkB with or without coexpression of its ligand, brain-derived ...
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In a screen for proteins that would prevent rat intestinal epithelial cell death caused by loss of cell attachment, so-called anoikis, Douma et al. identified the neurotrophin receptor tyrosine kinase TrkB. Further analysis showed that overexpression of TrkB with or without coexpression of its ligand, brain-derived ...
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The FASEB Journal, 2020
It has been documented that M2 macrophage polarization plays a suppressive role in atherosclerosis in diabetes mellitus (DM). In addition, prostaglandin E2 (PGE2) is implicated in the development of M2 macrophage polarization.
Chang-long Bi +3 more
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It has been documented that M2 macrophage polarization plays a suppressive role in atherosclerosis in diabetes mellitus (DM). In addition, prostaglandin E2 (PGE2) is implicated in the development of M2 macrophage polarization.
Chang-long Bi +3 more
semanticscholar +1 more source
Androgen regulates trkB immunolabeling in spinal motoneurons
Journal of Neuroscience Research, 2006AbstractNeurotrophic factors and steroid hormones have been shown to have neuroprotective/neurotherapeutic effects, and it has been shown previously that brain‐derived neurotrophic factor (BDNF) and testosterone have a combinatorial effect in the maintenance of motoneurons.
M C, Osborne +2 more
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The FASEB Journal, 2020
Prostate cancer (PCa) is one of the most common malignant diseases in male worldwide, yet, the molecular mechanisms involved in PCa progression are still poorly understood.
Tao Li +7 more
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Prostate cancer (PCa) is one of the most common malignant diseases in male worldwide, yet, the molecular mechanisms involved in PCa progression are still poorly understood.
Tao Li +7 more
semanticscholar +1 more source
Expression of TrkB in the murine kidney
Microscopy Research and Technique, 2006AbstractNeurotrophins acting through Trk signal‐transducing receptors play essential roles in the nervous system, and probably in some nonneuronal tissues. In the present study we used Western‐blot and immunohistochemistry to investigate the occurrence and cellular localization of TrkB in the mouse kidney.
GARCIA SUAREZ O +8 more
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TrkB mRNA and protein in mouse spleen: structure of the spleen of functionally deficient TrkB mice
Cell and Tissue Research, 2004Whereas it is nowadays clear that neurotrophins are involved in the regulation of various aspects of the functioning of immune system, knowledge of their actual immunomodulatory roles is still fragmentary and incomplete. In this respect, knock-out mouse models remain particularly unexplored. In the present study, the expression of the TrkB neurotrophin
PEREZ PEREZ M +8 more
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Targeting TrkB neurotrophin receptor to treat depression
Expert Opinion on Therapeutic Targets, 2008An increasing number of findings point out the key role of the BDNF (brain-derived neurotrophic factor) receptor, tyrosine kinase receptor B (TrkB), in the regulation of antidepressant drug actions. Therefore, targeting TrkB receptors might be a rational strategy to develop novel antidepressant drugs.In this review we will discuss several approaches to
Tomi, Rantamäki, Eero, Castrén
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Neurotrophin-evoked rapid excitation through TrkB receptors
Nature, 1999Neurotrophins are a family of structurally related proteins that regulate the survival, differentiation and maintenance of function of different populations of peripheral and central neurons. They are also essential for modulating activity-dependent neuronal plasticity. Here we show that neurotrophins elicit action potentials in central neurons.
K W, Kafitz +3 more
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