Results 21 to 30 of about 54,934 (280)

Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures

Frontiers in Pharmacology, 2021
Background: Baicalin (BCL), a candidate drug for ischemic stroke, has been indicated to protect neurons by promoting brain-derived neurotrophic factor (BDNF).
Changxiang Li, Cong Sui, W. Wang, Juntang Yan, Nan Deng, Xin Du, F. Cheng, Xiaona Ma, Xueqian Wang, Qingguo Wang   +9 more
semanticscholar   +1 more source

miR-200c sensitizes breast cancer cells to doxorubicin treatment by decreasing TrkB and Bmi1 expression. [PDF]

, 2012
Acquired resistance to classical chemotherapeutics is a major obstacle in cancer treatment. Doxorubicin is frequently used in breast cancer therapy either as single-agent or in combination with other drugs like docetaxel and cyclophosphamide.
Kopp, Florian, Oak, Prajakta S., Roidl, Andreas, Wagner, Ernst   +3 more
core   +6 more sources

TrkB and the calpain dependent-Tc TrkB receptor isoforms: possible neurological therapeutic targets [PDF]

Journal of Neurology and Neuromedicine, 2016
Fil: Cragnolini, Andrea Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales.
Danelon, Víctor, Cragnolini, Andrea Beatriz, Masco, Daniel Hugo   +2 more
openaire   +3 more sources

A TrkB agonist prodrug prevents bone loss via inhibiting asparagine endopeptidase and increasing osteoprotegerin

Nature Communications, 2022
Brain-derived neurotrophic factor (BDNF) and its tropomyosin-related kinase B receptor (TrkB) are expressed in human osteoblasts and mediate fracture healing.
Jing Xiong, Jianming Liao, Xia Liu, Zhaohui Zhang, Jonathan W. Adams, R. Pacifici, K. Ye   +6 more
semanticscholar   +1 more source

Emodin Promotes Autophagy and Prevents Apoptosis in Sepsis-Associated Encephalopathy through Activating BDNF/TrkB Signaling

Pathobiology (Basel), 2021
Objective: Sepsis-associated encephalopathy (SAE) is a severe and common complication of sepsis and can induce cognitive dysfunction and apoptosis of neurons and neuroinflammation. Emodin has been confirmed to have anti-inflammatory effects.
Lihua Gao, Zhihao Wang, Yuyuan Mu, Zuolong Liu, L. Pang   +4 more
semanticscholar   +1 more source

Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity

Heliyon, 2023
Tropomyosin receptor kinase B (TrkB) serves as a pivotal factor in various cancers. To identify novel natural compounds with TrkB-inhibiting properties, a screening approach was applied using extracts from a collection of wild and cultivated mushroom ...
Orr Shahar, Idan Pereman, Hazem Khamisie, Nirit Ezov, Ofer Danay, Ali Khattib, Ron schweitzer, Soliman Khatib, Jamal Mahajna   +8 more
doaj   +1 more source

The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases

Life, 2021
Brain-derived neurotrophic factor (BDNF) is one of the most abundantneurotrophins in the central nervous system. Numerous studies suggestthat BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB), and ...
Peng-zhou Hang, Hua Zhu, Pei-feng Li, Jie Liu, Feng-qin Ge, Jing Zhao, Z. Du   +6 more
semanticscholar   +1 more source

BDNF-TrkB signaling-mediated upregulation of Narp is involved in the antidepressant-like effects of (2R,6R)-hydroxynorketamine in a chronic restraint stress mouse model

BMC Psychiatry, 2022
Background Preclinical studies have indicated that the ketamine metabolite ( 2R,6R )-hydroxynorketamine (HNK) is a rapid-acting antidepressant drug with limited dissociation properties and low abuse potential.
Lingsha Ju, Jiao-jiao Yang, Tingting Zhu, Panmiao Liu, Jianjun Yang   +4 more
semanticscholar   +1 more source

Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. [PDF]

PLoS ONE, 2011
BackgroundAntidepressant drugs (ADs) have been shown to activate BDNF (brain-derived neurotrophic factor) receptor TrkB in the rodent brain but the mechanism underlying this phenomenon remains unclear.
Tomi Rantamäki, Liisa Vesa, Hanna Antila, Antonio Di Lieto, Päivi Tammela, Angelika Schmitt, Klaus-Peter Lesch, Maribel Rios, Eero Castrén   +8 more
doaj   +1 more source

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

Journal of Neuroinflammation, 2020
Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by cognitive impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear.
L. Qiu, W. Pan, Dan Luo, Guang-fen Zhang, Zhi-qiang Zhou, Xiaoyun Sun, Jian-jun Yang, M. Ji   +7 more
semanticscholar   +1 more source