Modulation of neurotrophic signaling pathways by polyphenols [PDF]
, 2015 Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza +3 more
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Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
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Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma. [PDF]
PLoS ONE, 2013 Mechanisms governing the metastasis of endometrial carcinoma (EC) are poorly defined. Recent data support a role for the cell surface receptor tyrosine kinase TrkB in the progression of several human tumors.
Wei Bao +5 more
doaj +1 more source
Activation of adenosine A2A receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts : implications for neuromodulation [PDF]
, 2010 Copyright © 2010 the authorsBrain-derived neurotrophic factor (BDNF) signaling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been hown to be necessary for the activation of specific signaling ...
Assaife-Lopes, Natália +5 more
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The Effect of a 6-week Endurance Training on BDNF and TrKB Gene Expression in the Soleus of Rats with Diabetic Neuropathy [PDF]
Journal of Kerman University of Medical Sciences, 2016 Background & Aims: Diabetic neuropathy can lead to atrophy and weakness of distally located muscles and lack of neurotrophic support is believed to contribute to the development of these consequences.
Ramin Rashidi Molaei +2 more
doaj
Sophisticated sperm allocation in male fowl [PDF]
, 2003 When a female is sexually promiscuous, the ejaculates of different males compete for the fertilization of her eggs; the more sperm a male inseminates into a female, the more likely he is to fertilize her eggs.
Pizzari, T. +4 more
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Extracellular Juxtamembrane Motif Critical for TrkB Preformed Dimer and Activation
Cells, 2019 Receptor tyrosine kinases are believed to be activated through ligand-induced dimerization. We now demonstrate that in cultured neurons, a substantial amount of endogenous TrkB, the receptor for brain-derived neurotrophic factor (BDNF), exists as an ...
Jianying Shen +6 more
doaj +1 more source
The responsiveness of TrkB to BDNF and antidepressant drugs is differentially regulated during mouse development. [PDF]
PLoS ONE, 2012 Previous studies suggest that the responsiveness of TrkB receptor to BDNF is developmentally regulated in rats. Antidepressant drugs (AD) have been shown to increase TrkB signalling in the adult rodent brain, and recent findings implicate a BDNF ...
Antonio Di Lieto +8 more
doaj +1 more source
Neurobiology of Disease, 2023 L-DOPA-induced dyskinesia (LID) is a frequent adverse side effect of L-DOPA treatment in Parkinson's disease (PD). Understanding the mechanisms underlying the development of these motor disorders is needed to reduce or prevent them.
Assunta Pelosi +3 more
doaj +1 more source
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence [PDF]
, 2011 Depression is a neuropsychiatric disorder affecting a huge percentage of the active population especially in developed countries. Research has devoted much of its attention to this problematic and many drugs have been developed and are currently ...
Berrocoso Domínguez, Esther María +4 more
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