Results 71 to 80 of about 54,934 (280)

Truncated TrkB: The predominant TrkB Isoform in Nociceptors

The Journal of Pain
AbstractTruncated TrkB (TrkBT1), traditionally considered a dominant-negative regulator of full-length TrkB (TrkBTK+), remains poorly understood in peripheral sensory neurons, particularly nociceptors. Furthermore, sensory neuronal TrkB expression and function has been traditionally associated with non-nociceptive neurons, particularly Aδ low-threshold
Jaclyn Merlo, Fang-Mei Chang, Michael Tran, Jessie Alfaro, Tarek Ibrahim, Ping Wu, Shivani Ruparel   +6 more
openaire   +3 more sources

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

Cell Reports, 2018
Summary: Brain-derived neurotrophic factor (BDNF) and its high-affinity receptor, tropomyosin receptor kinase B (TrkB), regulate long-term potentiation (LTP) in the hippocampus, although the sites of BDNF-TrkB receptors in this process are controversial.
Pei-Yi Lin, Ege T. Kavalali, Lisa M. Monteggia   +2 more
doaj   +1 more source

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. [PDF]

, 2017
Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft ...
Chang, Ting-Ya, Chang, Ya-Chu, Chen, Chen, Cheng, Pei-Lin, Guo, Chin-Lin, Lee, Min, Lu, Chi-Huan, Lu, Shao-Tzu, Wang, Aijun, Wang, De-Yao   +9 more
core   +2 more sources

Optical activation of TrkB receptors [PDF]

, 2019
AbstractBrain-derived neurotrophic factor (BDNF), via activation of tropomyosin receptor kinase B (TrkB), plays a critical role in neuronal proliferation, differentiation, survival, and death. Dysregulation of TrkB signaling is implicated in neurodegenerative disorders and cancers.
Huang, Peiyuan, Liu, Aofei, Song, Yutong, Hope, Jen M., Cui, Bianxiao, Duan, Liting   +5 more
openaire   +1 more source

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance New effective therapies are desperately needed for lung cancer because most current lung cancer treatments rarely prevent the metastatic disease that causes the majority of patient deaths. We discovered that the neurotrophin receptor TrkB is an important therapeutic target in metastatic lung cancer using a combination of cell ...
Kerstin W, Sinkevicius, Christina, Kriegel, Kelly J, Bellaria, Jaewon, Lee, Allison N, Lau, Kristen T, Leeman, Pengcheng, Zhou, Alexander M, Beede, Christine M, Fillmore, Deborah, Caswell, Juliana, Barrios, Kwok-Kin, Wong, Lynette M, Sholl, Thorsten M, Schlaeger, Roderick T, Bronson, Lucian R, Chirieac, Monte M, Winslow, Marcia C, Haigis, Carla F, Kim   +18 more
openaire   +2 more sources

Brain-derived neurotrophic factor (BDNF)-induced tropomyosin-related kinase B (Trk B) signaling is a potential therapeutic target for peritoneal carcinomatosis arising from colorectal cancer. [PDF]

PLoS ONE, 2014
Tropomyosin-related receptor kinase B (TrkB) signaling, stimulated by brain-derived neurotrophic factor (BDNF) ligand, promotes tumor progression, and is related to the poor prognosis of various malignancies.
Koji Tanaka, Yoshinaga Okugawa, Yuji Toiyama, Yasuhiro Inoue, Susumu Saigusa, Mikio Kawamura, Toshimitsu Araki, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki   +9 more
doaj   +1 more source

BDNF/TrkB axis activation promotes epithelial-mesenchymal transition in idiopathic pulmonary fibrosis [PDF]

, 2017
Background: Neurotrophins (NT) belongs to a family of growth factors which promotes neurons survival and differentiation. Increasing evidence show that NT and their receptor are expressed in lung tissues suggesting a possible role in lung health and ...
Bruno, Pierdonato, Cardillo, Giuseppe, Cherubini, Emanuela, D'Ascanio, Michela, Mancini, Rita, Mariotta, Salvatore, Osman, GIORGIA AMIRA, Ricci, Alberto, Scozzi, Davide   +8 more
core   +1 more source

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Frontiers in Pharmacology, 2019
Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation.
Huaiqing Luo, Y. Xiang, X. Qu, Hui-jun Liu, Chi Liu, Guang-yi Li, Liping Han, X. Qin   +7 more
semanticscholar   +1 more source

Astrocytic BDNF and TrkB regulate severity and neuronal activity in mouse models of temporal lobe epilepsy

Cell Death and Disease, 2020
Astrocytes have emerged as crucial regulators of neuronal network activity, synapse formation, and underlying behavioral and cognitive processes. Despite some pathways have been identified, the communication between astrocytes and neurons remains to be ...
S. Fernández-García, A. Sancho-Balsells, Sophie Longueville, D. Hervé, A. Gruart, J. Delgado-García, J. Alberch, A. Giralt   +7 more
semanticscholar   +1 more source

TrkB agonistic antibodies superior to BDNF: Utility in treating motoneuron degeneration

Neurobiology of Disease, 2019
While Brain-derived Neurotrophic Factor (BDNF) has long been implicated in treating neurological diseases, recombinant BDNF protein has failed in multiple clinical trials.
Wei Guo, Keliang Pang, Yanbo Chen, Shudan Wang, Heng Li, Yihua Xu, Fang Han, Hongyang Yao, Hang Liu, Vanessa Lopes-Rodrigues, Dang Sun, Jingyu Shao, Jianying Shen, Yang Dou, Wen Zhang, He You, Wutian Wu, Bai Lu   +17 more
doaj   +1 more source