Results 81 to 90 of about 54,934 (280)

Function and Mechanisms of Truncated BDNF Receptor TrkB.T1 in Neuropathic Pain

Cells, 2020
Brain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has been lauded for its pro-survival characteristics and involvement in both development and recovery of function within the central nervous system (CNS).
T. Cao, Jessica J. Matyas, C. Renn, A. Faden, S. Dorsey, Junfang Wu   +5 more
semanticscholar   +1 more source

Genetic knockout of NTRK2 by CRISPR/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells

Frontiers in Cellular Neuroscience, 2023
The tropomyosin receptor kinase B (TrkB) is encoded by the NTRK2 gene. It belongs to the family of transmembrane tyrosine kinases, which have key roles in the development and maintenance of the nervous system. Brain-derived neurotrophic factor (BDNF) and
Audrey Roussel-Gervais, Stéphanie Sgroi, Yves Cambet, Sylvain Lemeille, Tamara Seredenina, Karl-Heinz Krause, Vincent Jaquet, Vincent Jaquet   +7 more
doaj   +1 more source

Expression of Neurotrophins and Their Receptors Tropomyosin-related kinases (Trk) under Tension-stress during Distraction Osteogenesis [PDF]

, 2006
The localization and expression of neurotrophins and their receptors during distraction osteogenesis was investigated in 72 male rat femurs (11 weeks old) to further clarify the concurrence of cellular and molecular events of new bone formation.
Aiga, Ayako, Asaumi, Koji, Kadota, Hiroaki, Lee, You Jin, Mitani, Shigeru, Ozaki, Toshifumi, Takigawa, Masaharu   +6 more
core   +1 more source

Enteric glial cells express full-length TrkB and depend on TrkB expression for normal development

Neuroscience Letters, 2009
The embryonic development of the enteric nervous system (ENS) from neural crest precursor cells requires neurotrophic signaling. Neurotrophins (NTs) are a family of growth factors that bind Trk receptors to signal diverse functions, including development and maintenance of different cell populations in the peripheral nervous system.
LEVANTI, Maria, Esteban I., CIRIACO, Emilia, Pérez Piñera P., Cabo R., García Suarez O., Pardo B., Silos Santiago I., Cobo J, Vega J. A.   +9 more
openaire   +4 more sources

Srp20 regulates TrkB pre‐mRNA splicing to generate TrkB‐Shc transcripts with implications for Alzheimer’s disease [PDF]

Journal of Neurochemistry, 2012
AbstractPreviously, we reported elevated levels of the neuron‐specific tropomyosin receptor kinase B (TrkB) transcript, TrkB‐ sarc homology containing (Shc) in the hippocampus of Alzheimer’s disease (AD) brains. In this study, we determined how TrkB‐Shc transcripts are increased in AD. Utilizing a TrkB minigene transiently transfected into SHSY5Y cells,
Wong, JCY, Garner, B, Halliday, GM, Kwok, JBJ   +3 more
openaire   +3 more sources

Legumain Functions as a Transient TrkB Sheddase

International Journal of Molecular Sciences, 2023
While primarily found in endo-lysosomal compartments, the cysteine protease legumain can also translocate to the cell surface if stabilized by the interaction with the RGD-dependent integrin receptor αVβ3. Previously, it has been shown that legumain expression is inversely related to BDNF-TrkB activity.
Christoph Holzner, Katharina Böttinger, Constantin Blöchl, Christian G. Huber, Sven O. Dahms, Elfriede Dall, Hans Brandstetter   +6 more
openaire   +2 more sources

Few‐Layered Conductive Graphene Foams for Electrical Transdifferentiation of Mesenchymal Stem Cells Into Schwann Cell‐Like Phenotypes

Advanced Healthcare Materials, EarlyView.
Few‐layered three dimansional conductive graphene foams are promising cytocompatible platforms to transdifferentiate mesenchymal stem cells into Schwann cell‐like phenotypes using electrical and microstructural cues. Applied electrical stimulation conditions resulted in activation of MAPK, neurotrphin and RAS signaling pathways that led to upregulation
Ekin G. Simsar, Peifu Cheng, Tugce Dogruel, Maxsam Donta, Juhyung Jung, Naomi A. Asante, Donald S. Sakaguchi, Surya K. Mallapragada, Piran R. Kidambi, Metin Uz   +9 more
wiley   +1 more source

TrkB expression and dependence divides gustatory neurons into three subpopulations

Neural Development, 2019
Background During development, gustatory (taste) neurons likely undergo numerous changes in morphology and expression prior to differentiation into maturity, but little is known this process or the factors that regulate it.
Jennifer Rios-Pilier, Robin F. Krimm
doaj   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Cooperation of tyrosine kinase receptor TrkB and epidermal growth factor receptor signaling enhances migration and dispersal of lung tumor cells. [PDF]

PLoS ONE, 2014
TrkB mediates the effects of brain-derived neurotrophic factor (BDNF) in neuronal and nonnneuronal cells. Based on recent reports that TrkB can also be transactivated through epidermal growth-factor receptor (EGFR) signaling and thus regulates migration ...
Rudolf Götz, Michael Sendtner
doaj   +1 more source