Results 231 to 240 of about 185,424 (265)

tRNA hopping: effects of mutant tRNAs

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 2003
Movement of tRNA and mRNA through the ribosome is coupled. However, selection for suppression of a -1 frameshift mutation in Escherichia coli has yielded a class of mutant tRNAs that can violate this mechanism and "hop" or disengage from their cognate codons and re-pair downstream in the mRNA.
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Binding of Formylmethionyl-tRNA and Aminoacyl-tRNA to Ribosomes

Nature, 1968
Inhibition of aminoacyl-tRNA binding by the purified initiation factors f1 and f2 could be regarded as a mechanism for ensuring that only F-met-tRNA binds initially to the entry site, thereby preventing random or non-specific binding by aminoacyl-tRNA.
T, Ohta, R E, Thach
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The methylation of tRNA

Biochimie, 1976
The methylation of tRNA is a post-transcriptional modification which is achieved by specific enzymes, the tRNA methylases, with S adenosylmethionine as a methyl donor. The level and pattern of methylation are characteristic of the tRNA species and origin. Abnormally methylated tRNAs have been obtained, in vivo and in vitro, by a variety of methods, and
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Import of tRNAs and aminoacyl-tRNA synthetases into mitochondria

Current Genetics, 2008
During evolution, most of the bacterial genes from the ancestral endosymbiotic alpha-proteobacteria at the origin of mitochondria have been either lost or transferred to the nuclear genome. A crucial evolutionary step was the establishment of macromolecule import systems to allow the come back of proteins and RNAs into the organelle. Paradoxically, the
Anne-Marie, Duchêne, Claire, Pujol, Laurence, Maréchal-Drouard   +2 more
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The specificity of aminoacylation: a tRNA-tRNA interaction model

Journal of Theoretical Biology, 1978
Abstract Most of the isoacceptor species for a particular tRNA can be classified according to the middle base in the anticodon together with the fourth base in the amino acid stem. These specifying nucleotides would operate if a tRNA-tRNA interaction occurs on the aminoacyl-tRNA synthetase so that the anticodon of one tRNA molecule faces the fourth ...
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Reaction of Aminoacyl-tRNA Synthetases with Heterologous tRNA's

1971
Publisher Summary This chapter reviews that the incorporation of an amino acid into a peptide chain involves, first, the reaction of the amino acid and ATP with a specific enzyme to form an enzyme complex with aminoacyl-adenylate (E. AA-AMP), and second, the reaction of this complex with a specific tRNA to form an ester of the amino acid with the 2'-
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The expanding world of tRNA modifications and their disease relevance

Nature Reviews Molecular Cell Biology, 2021
Tsutomu Suzuki, Suzuki Tsutomu
exaly  

Design, construction, and functional characterization of a tRNA neochromosome in yeast

Cell, 2023
Yizhi Cai, Jitong Cai
exaly  

Unexpected Functions of tRNA and tRNA Processing Enzymes

2011
tRNA and tRNA processing enzymes impact more than protein production. Studies have uncovered roles for tRNA in the regulation of transcription, translation and protein turnover. Induced by stress or as a programmed part of development, nonrandom tRNA fragments can guide mRNA cleavage, inhibit translation and promote morphological changes.
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On the Recognition of tRNA by Its Aminoacyl-tRNA Liqase

1971
Publisher Summary This chapter reviews that experiments testing the adaptor hypothesis have shown conclusively that mRNA translation by aminoacyl-tRNA is independent of the amino acid attached to the tRNA. This means that esterification of the tRNA, catalyzed by its aminoacyl-tRNA ligase, must be specific if mistaken insertions of amino acids into ...
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