Results 81 to 90 of about 3,053 (170)

A severe asthma phenotype of excessive airway Haemophilus influenzae relative abundance associated with sputum neutrophilia

Clinical and Translational Medicine, Volume 14, Issue 9, September 2024.
The relative dominant species (RDS) in 51 sputum samples of severe asthma patients are described including Haemophilus influenzae, Moraxella catarrhalis and Tropheryma whipplei RDSs. Hierarchical clustering revealed 2 clusters, one entirely composed of Haemophilus influenzae with relative abundance of 76.3%.
Ali Versi, Adnan Azim, Fransiskus Xaverius Ivan, Mahmoud I Abdel‐Aziz, Stewart Bates, John Riley, Mohib Uddin, Nazanin Zounemat Kermani, Anke‐H Maitland‐Van Der Zee, Sven‐Eric Dahlen, Ratko Djukanovic, Sanjay H Chotirmall, Peter Howarth, Ian M Adcock, Kian Fan Chung, the U‐BIOPRED study group   +15 more
wiley   +1 more source

Never say never

Journal of Hospital Medicine, Volume 21, Issue 2, Page 200-204, February 2026.
Gurpreet Dhaliwal, Jagmeet Dhingra, Tom Fraser, Leal Herlitz, James Pile   +4 more
wiley   +1 more source

Endotypes of severe neutrophilic and eosinophilic asthma from multi‐omics integration of U‐BIOPRED sputum samples

Clinical and Translational Medicine, Volume 14, Issue 7, July 2024.
Multi‐omics analysis of asthma sputum identified five omics‐associated clusters (OAC1‐5). OAC2–OAC4 consist of patients with severe asthma while OAC1 and OAC5 mainly contain mild‐to‐moderate asthmatics. OAC3 represents a Th2 eosinophilic cluster. OAC2 and OAC4 are distinct severe mixed and neutrophilic asthma clusters with different neutrophil subtypes
Nazanin Zounemat Kermani, Chuan‐Xing Li, Ali Versi, Yusef Badi, Kai Sun, Mahmoud I Abdel‐Aziz, Martina Bonatti, Anke‐Hilse Maitland‐van der Zee, Ratko Djukanovic, Åsa Wheelock, Sven‐Erik Dahlen, Peter Howarth, Yike Guo, Kian Fan Chung, Ian M. Adcock, U‐BIOPRED Project Team   +15 more
wiley   +1 more source

Etiologic Diagnosis of Infective Endocarditis by Broad-Range Polymerase Chain Reaction: A 3-Year Experience [PDF]

, 2017
We analyzed surgically resected endocardial specimens from 49 patients by broad-range PCR. PCR results were compared with (1) results of previous blood cultures, (2) results of culture and Gram staining of resected specimens, and (3) clinical data (Duke ...
Altwegg, Martin, Bosshard, Philipp Peter, Böttger, Erik Christian, Kronenberg, Andreas, Ruef, Christian, Zbinden, Reinhard   +5 more
core  

Efficacy of Paromomycin-Chloroquine Combination Therapy in Experimental Cutaneous Leishmaniasis. [PDF]

, 2017
The 4-aminoquinoline chloroquine (CQ) is clinically used in combination with doxycycline to cure chronic Q fever, as it enhances the activity of the antibiotic against the causative bacterium Coxiella burnetii residing within macrophage phagolysosomes ...
Croft, Simon L, Murdan, Sudaxshina, Van Bocxlaer, Katrien, Wijnant, Gert-Jan, Yardley, Vanessa   +4 more
core   +2 more sources

Infective endocarditis is rare in patients with hematologic malignancy and neutropenia

Transplant Infectious Disease, Volume 26, Issue 3, June 2024.
Infective endocarditis is rare among admitted patients with hematologic malignancy, and echocardiography is unlikely to improve patient‐centered outcomes. Abstract Background Infective endocarditis (IE) is a serious complication of bloodstream infections (BSIs) that occurs at variable rates depending on the pathogen and clinical setting.
Michael J. Scolarici, Leigh R. Berman, Natalie Callander, Jeannina Smith, Christopher Saddler   +4 more
wiley   +1 more source

Hybrid approach to management for a patient with culture negative infective endocarditis with profunda femoris mycotic pseudoaneurysm: A case report and review of the literature

Clinical Case Reports, Volume 12, Issue 3, March 2024.
Key Clinical Message Mycotic pseudoaneurysms can be a serious and life threatening complication of left sided infective endocarditis. They most commonly affect the major axial vessels. Profunda femoris artery (PFA) aneurysms are rare and present in only 0.5% of all peripheral aneurysms, regardless of the underlying etiology.
Fahad M. Alshair, Abdullah H. Baghaffar, Mazin A. Fatani, Reda A. jamjoom   +3 more
wiley   +1 more source

Late Relapse of Previous Pulmonary Cryptococcosis With Symptoms Resembling Cerebral Infarction: A Case Report

Case Reports in Infectious Diseases, Volume 2024, Issue 1, 2024.
Cryptococcosis, an infection caused by Cryptococcus neoformans and Cryptococcus gattii, predominantly targets the central nervous system (CNS) in patients with AIDS but is not limited to this group. The disease can also occur in individuals with various immunosuppressive conditions, frequently involving the brain or lungs.
Anatoli Pinchuk, Gernot Geginat, Volker Rickerts, Belal Neyazi, Klaus Peter Stein, Christian Mawrin, I. Erol Sandalcioglu, Ali Rashidi, Salim Surani   +8 more
wiley   +1 more source

Staphylococcus lugdunensis Endocarditis Presenting with Brain Abscesses and Temporal Vision Deficits

Case Reports in Infectious Diseases, Volume 2024, Issue 1, 2024.
Staphylococcus lugdunensis is a coagulase‐negative staphylococcal bacterium (CoNS) that colonizes the skin. While infectious endocarditis (IE) caused by S. lugdunensis is rare, it is noteworthy because it has been associated with an aggressive clinical course.
Matthew S. Linz, Diana Finkel, Eli S. Goshorn, Piyush Baindara   +3 more
wiley   +1 more source

An Incidental Finding of Whipple’s Disease Masquerading as Nonspecific, Long‐Standing Symptoms

Case Reports in Infectious Diseases, Volume 2024, Issue 1, 2024.
Whipple’s disease is a rare bacterial infection that is often present for years prior to diagnosis. Symptoms are nonspecific in the early stages of presentation and are primarily gastrointestinal in nature. The disease may progress with more systemic symptoms including arthralgia, fever, lymphadenopathy, cardiovascular disease, and central nervous ...
Thomas Tuggle, Alison I. Orvin, Christian Caveness, Christopher Ingram, Piyush Baindara   +4 more
wiley   +1 more source