Results 61 to 70 of about 233,008 (296)

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Graph hierarchy: a novel framework to analyse hierarchical structures in complex networks

Scientific Reports, 2021
Trophic coherence, a measure of a graph’s hierarchical organisation, has been shown to be linked to a graph’s structural and dynamical aspects such as cyclicity, stability and normality.
Giannis Moutsinas, Choudhry Shuaib, Weisi Guo, Stephen Jarvis   +3 more
doaj   +1 more source

Combined stable isotope and gut contents analysis of food webs in plant-dominated, shallow lakes [PDF]

, 2003
1. To determine feeding links between primary producers, invertebrates and fish, stable isotope analyses and gut content analyses of fish were conducted on the components of four shallow, eutrophic to hypertrophic, plant-dominated lakes. 2.
Adams, Ben-David, Brönmark, Brönmark, Burks, Canfield, Carpenter, Cattaneo, DeNiro, DeNiro, Diehl, Diehl, Fry, Fryer, Fryer, Gervais, Grey, Hecky, Hoyer, J. Iwan Jones, Jeppesen, Jeppesen, Jones, Jones, Jones, Jones, Jones, Kairesalo, Mackereth, Marklund, Mazumder, Moss, Pennock, Phillips, Phillips, Phillips, Sand-Jensen, Scheffer, Susan Waldron, Svanbäck, Thorpe, Timms, Vander-Zanden, Yoshii, Yoshioka, Zippin   +45 more
core   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Stability trophic cascades in food chains [PDF]

Royal Society Open Science, 2018
While previous studies have evaluated the change in stability for the addition or removal of individual species from trophic food chains and food webs, we know of no study that presents a general theory for how stability changes with the addition or ...
David W. Shanafelt, Michel Loreau
doaj   +1 more source

Evaluating the influence of lake morphology, trophic status and diagenesis on geochemical profiles in lake sediments [PDF]

, 2010
Recent geochemical studies provide evidence that changes in vertical distributions of nutrients in lake sediments are driven by anthropogenic activities, based primarily on trends of increasing concentrations in upper sediment layers.
Hamilton, David P., Pilditch, Conrad A., Trolle, Dennis   +2 more
core   +2 more sources

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Diet composition, niche overlap and partitioning of five sympatric rhinolophid bats in Southwestern China during summer

Frontiers in Ecology and Evolution, 2023
Understanding trophic niche differentiation is critical for exploring interspecific competition and stable coexistence among morphologically similar sympatric species.
Wentao Dai, Wentao Dai, Aoqiang Li, Yang Chang, Tong Liu, Lin Zhang, Jun Li, Haixia Leng, Zhongle Li, Longru Jin, Keping Sun, Keping Sun, Jiang Feng, Jiang Feng   +13 more
doaj   +1 more source

Effects of climate on size structure and functioning of aquatic food webs [PDF]

, 2010
In aquatic food webs, the role of body size is notoriously strong. It is also well known that temperature has an effect on body size. For instance, Bergmann’s rule states that body size increases from warm to cold climates.
Lacerot, G.
core  

OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain

Advanced Science, EarlyView.
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang, Honglin Tan, Colleen Russell, Mikolaj Walczak, Dawei Gao, Guanda Qiao, Xiaoxuan Fan, Chengyan Chu, Miroslaw Janowski, Piotr Walczak, Yajie Liang   +10 more
wiley   +1 more source