Results 71 to 80 of about 187,503 (276)

Bioconcentration, bioaccumulation, biomagnification and trophic magnification: a modelling perspective

open access: yesEnvironmental Science: Processes & Impacts, 2018
The uptake and output processes and lipid content for an aquatic organism affects BCF, BAF, BMF, and TMF values.
Donald Mackay   +3 more
openaire   +3 more sources

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu   +10 more
wiley   +1 more source

Marine mammal impacts in exploited ecosystems: would large scale culling benefit fisheries? [PDF]

open access: yesPLoS ONE, 2012
Competition between marine mammals and fisheries for marine resources-whether real or perceived-has become a major issue for several countries and in international fora.
Lyne Morissette   +2 more
doaj   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

open access: yesAdvanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan   +10 more
wiley   +1 more source

Using trophic models to assess the impact of fishing in the Bay of Biscay and the Celtic Sea

open access: yesAquatic Living Resources, 2017
Using the Bay of Biscay and Celtic Sea area as a case study, we showed how stock-assessments and trophic models can be useful and complementary tools to quantify the fishing impacts on the whole food web and to draw related diagnoses at the scale of ...
Bentorcha Abdelkrim   +2 more
doaj   +1 more source

Species assembly in model ecosystems, I: Analysis of the population model and the invasion dynamics [PDF]

open access: yes, 2010
Recently we have introduced a simplified model of ecosystem assembly (Capitan et al., 2009) for which we are able to map out all assembly pathways generated by external invasions in an exact manner. In this paper we provide a deeper analysis of the model,
Alonso   +46 more
core   +7 more sources

Reducing the Eltonian shortfall with trophic interaction models

open access: yes, 2021
While species interactions are fundamental for linking biodiversity to ecosystem functioning and for conservation, large-scale empirical data are lacking for most species and ecosystems. Accumulating evidence suggests that trophic interactions are predictable from available functional trait information, but we have yet to understand how well we can ...
Dominique Caron   +3 more
openaire   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

open access: yesAdvanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia   +11 more
wiley   +1 more source

Modelling for an improved integrated multi-trophic aquaculture system for the production of highly valued marine species

open access: yesFrontiers in Marine Science, 2014
Integrated multi-trophic aquaculture (IMTA) is regarded as a suitable approach to limit aquaculture nutrients and organic matter outputs through biomitigation.
Luana Granada, Sofia Lopes
doaj   +1 more source

Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co‐Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy

open access: yesAdvanced Science, EarlyView.
A multifunctional injectable microsphere system is fabricated via UV‐assisted microfluidic cross‐linking, integrating nanozyme‐based ROS scavenging, sustained dexamethasone release, and stem cell delivery. Upon IA injection, the microspheres adapt to joint stress, suppress inflammation, and promote cartilage regeneration, offering a minimally invasive ...
Xiaochen Feng   +10 more
wiley   +1 more source

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