Results 121 to 130 of about 122,259 (237)

Chemotherapy resistance and risk stratification in gestational trophoblastic neoplasia: A systematic review and network meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 11, Page 2158-2172, November 2026.
Higher pretreatment β‐hCG, greater tumor burden, higher FIGO stage/score, and choriocarcinoma were associated with higher chemoresistance risk in gestational trophoblastic neoplasia. In exploratory network analyses, etoposide‐containing regimens showed lower predicted chemoresistance.
Ying‐Ying Xue, Xin‐Yue Yang, Fang‐Yu Chen, Hui‐Ting Yang, Chao Zhang, Jin‐Zhu Yan, Shi‐Shi Wu, Long Wang   +7 more
wiley   +1 more source

Gestational trophoblastic disease: understanding the molecular mechanisms of placental tumours [PDF]

Gestational trophoblastic disease (GTD) describes a group of rare benign and cancerous lesions originating from the trophoblast cells of the placenta. These neoplasms are unconventional entities, being one of the few instances in which cancer develops ...
Benjamin Schuster-Böckler, Máire Ní Leathlobhair, Alina Nicheperovich   +2 more
core   +1 more source

A pro‐inflammatory cytokine signature characterises thrombotic antiphospholipid syndrome despite stable anticoagulation

British Journal of Haematology, Volume 209, Issue 5, Page 2233-2243, November 2026.
Primary antiphospholipid syndrome comprises distinct inflammatory subgroups defined by cytokine profiling. A shared pro‐inflammatory signature is present across all patients, whereas arterial thrombosis demonstrates enhanced inflammatory activation compared with venous thrombosis, suggesting divergent pathogenic mechanisms and opportunities for ...
Catherine B. Ducker, Megan V. Preece, Jeremy Schofield, Charis Pericleous, Mike Laffan, Simon Abrams, Deepa J. Arachchillage   +6 more
wiley   +1 more source

Revealing the Action Mechanism of WISP2 in Miscarriage Based Multi‐Omic Analysis and Experimental Validation

Chemical Biology &Drug Design, Volume 108, Issue 5, November 2026.
In this study, the single‐cell atlas at the maternal–fetal interface in normal and recurrent miscarriage (RM) samples showed 11 cell types, including DSCs and SCT/EVT cells. In SCT/EVT cells, WISP2 expression was markedly decreased in the RM cases. Elevated levels of WISP2 and E‐cadherin were detected in villous tissues of patients with RM.
Zhe Leng, Boyu Yan, Fang Wang, Xinyi Bian, Yu Huang, Hongjuan Lv, Zhou Jiang, Xianli Sun   +7 more
wiley   +1 more source

The clinicopathological features of intermediate trophoblastic tumor in the pineal region

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Objective To evaluate the clinicopathological features of intermediate trophoblastic tumor (ITT) in the pineal region. Methods A retrospective study was performed to analyse the diagnostic and therapeutic process of 1 case with ITT in the pineal region ...
Yun⁃xiang ZHANG, Ding⁃rong ZHONG, Ming⁃ming HU, Tao YUAN, Gui⁃lin LI   +4 more
doaj  

Early Metabolic Reprogramming in the Placenta Shapes Resilience to Gestational Hypoxia in High‐Elevation Deer Mice

Molecular Ecology, Volume 35, Issue 21, November 2026.
ABSTRACT Environmental hypoxia at high elevations is linked to increased rates of gestational complications. Evolutionary adaptation to high elevation environments mitigates these complications across mammals, in part through changes in placental function that shape foetal growth potential in late pregnancy.
Megan J. Hemmerlein, Anna Isabel Bautista, Ellery L. Myers, Jeffrey M. Good, Zachary A. Cheviron, Kathryn Wilsterman   +5 more
wiley   +1 more source

Rare neoplasms

, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
Valentina Ciaravino, CIARAVINO, VALENTINA, Roberto Malagò, MALAGO', Roberto, Roberto Pozzi Mucelli, Capelli, Paola, Paola Capelli, DE ROBERTIS LOMBARDI, Riccardo, PEDICA, Federica, Riccardo De Robertis, Federica Pedica, POZZI MUCELLI, Roberto   +11 more
core   +1 more source

Elevation of hCG in CSF in pinealoblastoma: a pitfall rescued by pathological examination

Acta Neuropathologica Communications
Human chorionic gonadotropin (hCG) is a hormone that may be abnormally secreted in several tumour types, including intracranial germ cell tumours. In pineal region tumors, hCG is a key tumor marker.
François Bouille, Karima Mokhtari, Bertrand Mathon, Jérôme Alexandre Denis, Lucia Nichelli, Ahmed Idbaih, François Doz, Alice Laurenge   +7 more
doaj   +1 more source

Circulating TGF‐β1 Increases During Vaginal Progesterone Therapy in Women With a Short Cervix

Scandinavian Journal of Immunology, Volume 104, Issue 5, November 2026.
Progesterone treatment was associated with increased plasma TGF‐β1 concentrations in pregnant women at risk of spontaneous preterm birth. These findings suggest that progesterone may enhance immunoregulatory pathways relevant to pregnancy maintenance, although the underlying mechanism remains to be established.
Zdeněk Laštůvka, Viktor Černý, Anna Škvorová, Petra Petrásková, Olga Novotná, Helena Kopřivová, Jiří Hrdý, Michal Koucký   +7 more
wiley   +1 more source

Hypoxia‐Driven CA2 Promotes Trophoblast Dysfunction in Preeclampsia

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
CA2 is upregulated in preeclampsia and impairs trophoblast function by suppressing VEGFA under hypoxia/HIF‐1α signaling. LNP‐mediated CA2 silencing improves placental structure and fetal outcomes, highlighting CA2 as a promising therapeutic target for PE.
Lujiao Chen, Chuchu Zhu, Jian Zhao, Lei Ye, Hetong Li, Haote Han, Ying Jiang, Qiong Luo   +7 more
wiley   +1 more source