Results 51 to 60 of about 319,242 (298)

Constitutional trisomy 8 as first mutation in multistep carcinogenesis: clinical, cytogenetic, and molecular data on three cases. [PDF]

, 1996
Three patients, with constitutional trisomy 8 mosaicism (CT8M), who developed a malignancy are reported. The diagnoses were refractory anaemia, acute lymphoblastic leukaemia, and idiopathic myelofibrosis.
ADDIS P., ANGIONI A., BALLONI P., CAVALLI P., DANESINO C.PASQUALI F., DELLAVECCHIA C., F. PASQUALI, LOCATELLI F., MASERATI E., MIANO C., MINELLI A., SEGHEZZI L.   +11 more
core   +1 more source

Molecular and immunohistochemical characteristics of complete hydatidiform moles

Balkan Journal of Medical Genetics, 2017
Molar pregnancy is a gestational trophoblastic disease that belongs to the category of precancerous lesions. On the other end of the spectrum are gestational trophoblastic neoplasms such as invasive mole, choriocarcinoma, placental site trophoblastic ...
Kubelka-Sabit KB, Prodanova I, Jasar D, Bozinovski G, Filipovski V, Drakulevski S, Plaseska-Karanfilska D   +6 more
doaj   +1 more source

Placental site trophoblastic tumor: a case report and review of the literature [PDF]

, 2015
We present a case of a gravida 1 para 1 woman, who presented with an 11- month history of amenorrhea after cesarean delivery. The patient was taking birth control pills at the time of presentation.
Cunha, Teresa Margarida, Lucas, Rita, Santos, Filipa Batista   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

MR appearance of placental site gestational trophoblastic neoplasm

Clinical Imaging, 1996
The magnetic resonance imaging (MRI) findings of a patient with placental site trophoblastic tumor are presented. In this patient, a small focal mass distorting the junctional zone and invading the myometrium was identified. Due to the aggressive nature of this neoplasm and the difficulty in detecting it clinically, MRI may represent a useful tool in ...
Norman A. Beauchamp, Janet E. Kuhlman
openalex   +3 more sources

Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma. [PDF]

PLoS ONE, 2017
The uterine corpus represents the most common site for tumour development in the female genital system. Uterine neoplasms are categorised as epithelial, mesenchymal, mixed epithelial-mesenchymal or trophoblastic tumours. In this study we employed a mouse
Laura P Brandt, Joachim Albers, Tomas Hejhal, Antonella Catalano, Peter J Wild, Ian J Frew   +5 more
doaj   +1 more source

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity

Biochemistry and Biophysics Reports, 2021
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT).
Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa   +7 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Pulmonary function in patients with trophoblastic disease treated with low-dose methotrexate [PDF]

, 1997
The Sheffield Trophoblastic Disease Centre treats about 25 patients with persistent trophoblastic disease each year. A total of 75% of patients are classified as low risk according to the Charing Cross Hospital prognostic scoring system and receive ...
Coleman, R. E., Gillespie, A. M., Hancock, B. W., Lorigan, P. C., Radstone, C. R., Waterhouse, J. C.   +5 more
core   +2 more sources