Results 51 to 60 of about 8,240 (228)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Core 2 β1,6-N-acetylglucosaminyltransferases accelerate the escape of choriocarcinoma from natural killer cell immunity

Biochemistry and Biophysics Reports, 2021
Hyperglycosylated human chorionic gonadotropin (H-hCG) is secreted from choriocarcinoma and contains a core2 O-glycan formed by core2 β1,6-N-acetylglucosaminyl transferase (C2GnT).
Kenichi Nakamura, Kaoru Niimi, Eiko Yamamoto, Yoshiki Ikeda, Kimihiro Nishino, Shiro Suzuki, Hiroaki Kajiyama, Fumitaka Kikkawa   +7 more
doaj   +1 more source

A Rational Optimization Approach for the Development of a Multiplexed Lateral Flow Immunoassay: Detection of Nonepithelial Ovarian Cancer Markers in Human Serum

Advanced Science, EarlyView.
This study outlines the developmental pipeline of a multiplexed nanozyme‐based lateral flow immunoassay for the purpose of ovarian germ cell tumor detection. It demonstrates the application of a design of experiments optimization approach for nanozyme probe conjugate development.
Aida Abdelwahed, Carl E. Eskildsen, Luca Panariello, André Shamsabadi, Christy J. Sadler, Edmund H. Wilkes, Federico Galvanin, Yuxi Cheng, Sara Carvalho, Srdjan Saso, Molly M. Stevens   +10 more
wiley   +1 more source

Significance of transvaginal Doppler ultrasonography for detection of malignant gestational trophoblastic disease [PDF]

Vojnosanitetski Pregled, 2005
Transvaginal Doppler ultrasonography has an important role in detecting and confirming the gestational trophoblastic disease (GTD). It can also be helpful in early detection of the malignant cases of GTD such as the invasion and protrusion of ...
Nikolić Branka, Rakić Snežana, Pavlović Dejan, Popovac Svetlana, Lukić Relja   +4 more
doaj   +1 more source

Circulating fatty acid synthase in pregnant women: relationship to blood pressure, maternal metabolism and newborn parameters. [PDF]

, 2016
The enzyme FASN (fatty acid synthase) is potentially related with hypertension and metabolic dysfunction. FASN is highly expressed in the human placenta.
Bassols, Judit, Bruel, Montserrat, Carreras-Badosa, Gemma, Ibáñez Toda, Lourdes, López Bermejo, Abel, Mendoza, Ericka, Prats Puig, Anna, Puig i Miquel, Teresa, Vázquez-Ruíz, Montserrat, Zegher, Francis de   +9 more
core   +2 more sources

From Cell‐Free Transcriptomes to Single‐Cell Landscapes: Biomarker Discovery and Originating Cell Alteration Analysis via Graph Matrix Factorization

Advanced Science, EarlyView.
CellFreeGMF traces plasma cfRNA to likely originating cell types by integrating single‐cell atlases with graph‐regularized matrix factorization. The method decomposes cfRNA profiles into sample–cell contributions to reconstruct pseudo single‐cell expression.
Wenxiang Zhang, Wenjing Zhang, Hang Wei, Shiyan Liu, Junliang Shang, Weijie Gong, Hanwen Cheng, Xiujuan Lei, Yuhui Kou, Baoguo Jiang   +9 more
wiley   +1 more source

Amenorrhea and elevated βhuman chorionic gonadotropin of unknown origin: An unexpected location of choriocarcinoma

Gynecologic Oncology Reports, 2021
Choriocarcinoma is a rare malignancy originating from trophoblastic cells that is known to arise from the placenta. In this report, we describe the case of a 28-year-old female who consulted for amenorrhea and elevated βhCG mimicking a pregnancy of an ...
Ichrak Ben Abdallah, Mona Mlika, Yosra Berrazega, Nesrine Mejri, Haifa Rachdi, Houda El Benna, Nouha Daoud, Soumaya Laabidi, Faouzi Mezni, Hamouda Boussen   +9 more
doaj   +1 more source

Association of endometrioid ovarian carcinoma arising from endometriosis, endometrioid endometrial carcinoma, and high-grade undifferentiated endometrial sarcoma. a case report [PDF]

, 2017
Endometriosis is a chronic disease that affects women of reproductive age. Malignant transformation in endometriosis is considered to be an unusual event, only occurring in 0.7-0.1% of cases.
Caserta, D., Di Benedetto, L., Guarino, A., Mallozzi, M.   +3 more
core   +1 more source

Understanding pre‐eclampsia and fetal growth restriction at high altitude: A narrative review

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pre‐eclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of maternal and perinatal morbidity and mortality worldwide. Both conditions are more frequent and severe at high altitudes due to physiological changes in oxygen availability and vascular adaptation.
Víctor S. Rangel, Juliana Malagón Castillo, Juan David Duarte, Mariana Abril Barreto, Alejandra Vivas Ramirez, José Alejandro Daza, Ángela María Ruiz‐Sternberg   +6 more
wiley   +1 more source

Pregnancy Outcomes and Postnatal Health From Transferred Mosaic Embryos Following Preimplantation Genetic Testing for Aneuploidy

iNew Medicine, EarlyView.
This illustration synthesizes the methods and conclusion of this study, demonstrating that the transfer of mosaic embryos following reimplantation genetic testing for aneuploidy does not increase the risk to postnatal health. ABSTRACT Next‐generation sequencing (NGS) has increased the detection of mosaic embryos during preimplantation genetic testing ...
Lili Chen, Dehuan Huang, Jingcheng Sang, Yiqi Yin, Caiyun Wu, Yan Hao, Dawei Chen, Zhiguo Zhang, Yunxia Cao, Ri‐Cheng Chian, Ping Zhou   +10 more
wiley   +1 more source