Results 121 to 130 of about 92,904 (199)

Gestational Trophoblastic Disease

, 2019
The diagnosis of gestational trophoblastic disease has witnessed revolutionary changes with improved availability of immunohistochemistry and genotyping as valuable adjuncts.
Wang, RW, Cheung, ANY
core   +1 more source

Small Proteoglycans, Big Impact: Decorin, Biglycan, and Asporin in Musculoskeletal Tissue Health and Disease

Proteoglycan Research, Volume 4, Issue 4, October 2026.
ABSTRACT The extracellular matrix (ECM) is a dynamic and information‐rich network that integrates structural support with biochemical and mechanical signaling. Among its key regulatory components are the Small Leucine‐Rich Proteoglycans (SLRPs), a family of matrix molecules that coordinate extracellular architecture with cell signaling.
Alessandra Leone, Zsuzsa Jenei‐Lanzl, Frank Zaucke   +2 more
wiley   +1 more source

p21-activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease

, 2010
Gestational trophoblastic disease (GTD) includes hydatidiform mole (HM), which can develop persistent gestational trophoblastic neoplasia requiring chemotherapy; choriocarcinoma, which is a frankly malignant tumor; placental site trophoblastic tumor; and
Chan, DCW, Kong, DSH, Ho, JWK, Yeung, MCW, Ngan, HYS, Siu, MKY, Cheung, ANY, Zhang, H   +7 more
core   +1 more source

Metformin Inhibits Trophoblast Ferroptosis by Suppressing ATF2 and Activating the PI3K/Akt/Nrf2 Pathway to Improve Gestational Diabetes Mellitus

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Metformin suppresses ATF2 expression, activating the PI3K/Akt pathway and promoting Nrf2 nuclear translocation. This upregulates GPX4, inhibiting ferroptosis in trophoblast cells. Erastin blocks system Xc−, depleting GSH and promoting ferroptosis. LY294002 and ML385 inhibit the pathway, validating the mechanism.
Dandan Xia, Yuhui Zhang, Wenjie Liu, Siyu Li, Chenying Zhang, Guangtong She, Huiyan Wang   +6 more
wiley   +1 more source

Downregulation of ASPP1 in gestational trophoblastic disease: Correlation with hypermethylation, apoptotic activity and clinical outcome

, 2011
Gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neoplasms such as choriocarcinomas and the potentially malignant hydatidiform moles, which may develop persistent disease requiring chemotherapy.
Lee, L, Cheung, AN, Mak, VC, Siu, MK, Mak, VCY, Ngan, HYS, Wong, OGW, Cheung, ANY, Ngan, HY, Wong, OG, Wong, ESY, Siu, MKY, Lu, Xin, Wong, ES, Lu, X   +14 more
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Whole genome uniparental isodisomy detected using single nucleotide polymorphism (SNP) microarray in molar pregnancy: a case report

Molecular Cytogenetics
Background Gestational trophoblastic neoplasms consist of complete and partial hydatidiform moles, both of which are considered aberrant conceptuses.
Onyinye O. Okonkwo, Veronica Ortega, Sheila Kane, Galina Aldrete, Paulina Ramirez, Philip T. Valente, Gopalrao V.N. Velagaleti   +6 more
doaj   +1 more source

The evolving role of immunotherapy in ovarian cancer

Cancer, Volume 132, Issue 18, 15 September 2026.
Abstract Ovarian cancer remains a major cause of gynecologic cancer mortality; and, although immune checkpoint inhibitors have transformed treatment in other solid tumors, their activity in ovarian cancer has been limited by tumor heterogeneity, an immunosuppressive tumor microenvironment, and the lack of robust predictive biomarkers.
Ana Carolina Veneziani, Laura Venegas, Amit M. Oza   +2 more
wiley   +1 more source

P63 expression in gestational trophoblastic disease: Correlation with proliferation and apoptotic dynamics

, 2009
p63 regulates cell growth and differentiation and contributes to tumorigenesis through its complex isoforms. Gestational trophoblastic disease encompasses a heterogeneous family of lesions with different malignant potential that arise from various ...
Hextan Yuen-Sheung Ngan, Hui-Juan Zhang, Wei-Chen Xue, Xue, WC, Ngan, HYS, Zhang, Hui-Juan, Annie Nga-Yin Cheung, Liao, Xiao-Yun, Xiao-Yun Liao, Cheung, ANY, Ngan, Hextan Yuen-Sheung, Siu, Michelle Kwan-Yee, Cheung, Annie Nga-Yin, Zhang, HJ, Xue, Wei-Chen, Siu, MKY, Michelle Kwan-Yee Siu, Liao, XY   +17 more
core   +1 more source

Expression of human chorionic gonadotropin beta in gastric carcinoma: A retrospective immunohistochemical study

Indian Journal of Medical and Paediatric Oncology, 2009
Context: Beta Human Chorionic Gonadotropin (βHCG), a marker of the trophoblastic neoplasm, is also secreted by non-trophoblastic neoplasms including gastric carcinomas. Its role in disease progression remains unclear.
Murhekar Kanchan, Anuratha Jayaram, Majhi Urmila, Rajkumar Thangarajan   +3 more
doaj  

Management of symptomatic uterine arteriovenous malformations after gestational trophoblastic disease: The Brazilian experience and possible role for depot medroxyprogesterone acetate and tranexamic acid treatment

, 2018
OBJECTIVE: To identify predictive variables of heavy vaginal bleeding from uterine arteriovenous malformation (uAVM) after gestational trophoblastic disease (GTD) and review outcomes with different treatment strategies.
Parente, Raphael Câmara Medeiros [UNESP], Sun, Sue Yazaki [UNESP], Braga, Antonio [UNESP], Madi, José Mauro [UNESP], Lin, Lawrence [UNESP], Horowitz, Neil S. [UNESP], Celeste, Roger Keller [UNESP], Berkowitz, Ross S. [UNESP], Elias, Kevin M. [UNESP], Viggiano, Maurício [UNESP], Lima, Lana [UNESP], Amim Junior, Joffre [UNESP], Filho, Jorge De Rezende [UNESP], Maestá, Izildinha [UNESP], Uberti, Elza [UNESP]   +14 more
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