Results 201 to 210 of about 3,066,087 (375)

Genetic Divergence and Antibody Expression Influence the N‐Glycomes of CHO‐K1 and CHO‐S Cells

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT While Chinese hamster ovary (CHO) cells continue to be the workhorse of recombinant therapeutic protein production, decades of genetic divergence in the industrially relevant CHO‐K1 and CHO‐S cell lines, are likely to have resulted in differing glycosylation capabilities. Glycosylation can influence the efficacy, serum half‐life, and safety of
Roberto Donini   +6 more
wiley   +1 more source

Coordinated gene expression within sustained STAT3‐associated chromatin conformations contributes to hepatocellular carcinoma progression

open access: yesCancer Communications, EarlyView.
Abstract Background Phosphorylated signal transducer and activator of transcription 3 (p‐STAT3) has emerged as a critical modulator of hepatocellular carcinoma (HCC) progression. However, its role in three‐dimensional (3D) chromatin conformation and the expression of genes linked to HCC aggressiveness remains largely unexplored.
Sunyoung Jang   +9 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

open access: yesHepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim   +12 more
wiley   +1 more source

Special Issue: Travel and Tropical Medicine. [PDF]

open access: yesTrop Med Infect Dis, 2021
Rashid H, Badahdah AM, Khatami A.
europepmc   +1 more source

Tropical Medicine & International Health

open access: yesTropical medicine & international health, 2017

semanticscholar   +1 more source

Secondary Metabolites Composition and Their Histochemical Localization in the Fruit of Piper malgassicum Papini, Palchetti, Gori and Rota Nodari (Piperaceae)

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT The anatomy, histochemistry, and secondary metabolite composition were investigated on the drupes of Piper malgassicum, one of the components of the spice voatsiperifery pepper. The high amount of piperine recorded with high‐performance liquid chromatography with photodiode‐array detection analysis was localized with histochemistry mainly ...
Sara Falsini   +11 more
wiley   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann   +25 more
wiley   +1 more source

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