Results 51 to 60 of about 4,338 (258)
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Background: Candida albicans may cause other chronic fungal infections in the human ear. Otomycosis is a common disease found in the general clinical setting of otolaryngology.
Mohammad Mohsien Alrufae +2 more
doaj +1 more source
La repercussió de l'onada de calor de 2003 en la població major de 65 anys de Barcelona i l'àrea metropolitana [PDF]
Les onades de calor eren un fenomen desconegut per la població fins fa pocs anys, i tot i que avui dia ja son més populars, les seves conseqüències passen molt més desapercebudes que la d'altres catàstrofes naturals.
Santiago Jiménez, Marta +2 more
core
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang +7 more
wiley +1 more source
Our promising smart window exhibits exceptional optical properties, enabling the indoor temperature reduction of 12°C during summer and delivering the annual energy savings of 14.2%–24.4% across mid–to–low latitudes. ABSTRACT Building energy consumption accounts for 20%–40% of global energy usage, with windows among the least energy–efficient ...
Cheng Wang +11 more
wiley +1 more source
Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia. Assignatura: Botànica farmacèutica. Curs: 2014-2015. Coordinadors: Joan Simon, Cèsar Blanché i Maria Bosch.Els materials que aquí es presenten són el recull de les fitxes ...
Albertí Sancho, Blanca +124 more
core
Coupled Above‐ and Belowground Ecosystem Stability Worldwide
Are the worlds above and below our feet in sync? This global exploration reveals an entangled fate between above‐ and belowground ecosystem stability. It identifies arid regions as hotspots for this coupling and highlights temperature stability as a vital safeguard for maintaining ecosystem balance across our warming planet.
Zexin Meng +18 more
wiley +1 more source
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Els determinants de la demografia dels nostres arbres [PDF]
En un estudi recent, investigadors de la UAB han utilitzat informació de diverses fonts per determinar quins eren els millors predictors del comportament demogràfic de les espècies d'arbres més abundants dels boscos d'Espanya.
Martínez Vilalta, Jordi,
core +1 more source
Let K be a field equipped with a valuation. Tropical varieties over K can be defined with a theory of Gr{\"o}bner bases taking into account the valuation of K.
Vaccon, Tristan, Yokoyama, Kazuhiro
core +2 more sources

