Results 91 to 100 of about 20,236 (253)
Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs
Frontiers in Pharmacology, 2020 The breakdown of blood-tear barrier that occurs with ocular pathology allows for large amounts of albumin to leak into the tear fluid. This process likely represents an important restriction to drug absorption in ophthalmology, as only the unbound drug ...
Lionel Sebbag +3 more
doaj +1 more source
Urocortin 2 Gene Transfer Improves Glycemic Control and Reduces Retinopathy and Mortality in Murine Insulin Deficiency. [PDF]
, 2020 Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events.
Bhargava, Raag +10 more
core
Effect of phenylephrine on static and dynamic accommodation. [PDF]
, 2019 PURPOSE: We tested the hypothesis that changes in accommodation after instillation of Phenylephrine Hydrochloride (PHCl) observed in some studies could be caused by changes in optics.
Alpern +39 more
core +1 more source
Health Science Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background and Aims Glaucoma is a leading cause of irreversible blindness worldwide, with a disproportionate burden in Sub‑Saharan Africa. Identifying sociodemographic and clinical determinants is critical for early detection and prevention. This study identified glaucoma risk factors in Ghanaians and evaluated their prognostic significance ...
Angelina Ampong +8 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 5, 15 March 2026.The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth +7 more
wiley +1 more source
Journal of Biomedical Materials Research Part A, Volume 114, Issue 3, March 2026.ABSTRACT Age‐related macular degeneration (AMD) is a leading cause of irreversible vision loss in the aging population, with no curative treatment currently available. Current therapies primarily target late‐stage symptoms and are limited by their frequent and invasive intravitreal (IVT) injections.
Amna Abdalbaqi +4 more
wiley +1 more source
Laser &Photonics Reviews, Volume 20, Issue 5, 6 March 2026.In this work, we investigated the dynamic retinal pathology of glaucoma from onset to late stages through longitudinal in vivo high‐resolution imaging in a silicone oil‐induced ocular hypertension (SOHU) glaucoma mouse model. We developed an optimized adaptive optics two‐photon excitation fluorescence microscopy (AO‐TPEFM) technique for morphological ...
Yiming Fu +6 more
wiley +1 more source
Mydriasis as a Secondary Effect in Patients With HLA‐B27–Associated Uveitis
Medicine Advances, Volume 4, Issue 1, Page 12-19, March 2026.HLA‐B27‐associated acute anterior uveitis causes significant inflammation of the iris and anterior chamber, which disrupts normal parasympathetic control and results in increased sympathetic tone leading to pupil dilation (mydriasis). This finding can sometimes resemble herpetic uveitis, making a clinical context and careful evaluation crucial for ...
Saim Mahmood Khan +6 more
wiley +1 more source
BMC Ophthalmology, 2017 Backgroud To evaluate the manifestations of increased esodeviation under cycloplegia with 0.5% tropicamide and 0.5% phenylephrine in children with hyperopia and esotropia. Methods We reviewed the medical record of 34 children with hyperopia and esotropia
In Jeong Lyu, Kyung-Ah Park, Sei Yeul Oh
doaj +1 more source
RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells. [PDF]
, 2015 A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions.
Berson, David M +8 more
core +2 more sources