Results 101 to 110 of about 32,249 (223)
Indonesian Journal of Pharmacy, 2014 Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/B phosphorylation on Tyr490/Tyr516 of TMTtreated mice in a time-dependent manner.
Tran Phi Hoang Yen +4 more
openaire +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Marine Drugs, 2018 Perfluorooctane sulfonate (PFOS), a stable fluorosurfactant, causes endoplasmic reticulum (ER) stress in the brain. This study was designed to investigate whether a phycoerythrin-derived peptide of Pyropia yezoensis (PYP) reduces PFOS-induced ER stress ...
Jeong Hwan Oh +2 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
eLife, 2017 Lithium is widely used as a treatment for Bipolar Disorder although the molecular mechanisms that underlie its therapeutic effects are under debate.
Erinn S Gideons +4 more
doaj +1 more source
Functional Classification of Skeletal Muscle Networks. I. Normal Physiology [PDF]
, 2012 Extensive measurements of the parts list of human skeletal muscle through transcriptomics and other phenotypic assays offer the opportunity to reconstruct detailed functional models.
Subramaniam, Shankar +2 more
core +2 more sources
Glial cells in the heart: Implications for their roles in health and disease
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of cardiac autonomic ganglia within epicardial fat pads (posterior heart surface shown), containing vagal postganglionic neuron cell bodies, associated fibres, and glia. These ganglia receive cholinergic input from vagal preganglionic neurons and adrenergic input from sympathetic postganglionic neurons ...
Svetlana Mastitskaya +2 more
wiley +1 more source
The central benefit of physiologically induced ketogenic states
The Journal of Physiology, EarlyView.Abstract figure legend This review describes the association between ketogenic states induced by physiological interventions such as fasting or aerobic exercise, exogenous ketone supply and ketogenic diets, as well as increased cognition through increased activity of brain‐derived neurotrophic factor (BDNF).
Antonia Giacco +6 more
wiley +1 more source
Tyrosine kinase as therapeutic target of neurodegenerative disorders
Brain DisordersClasses of hereditary and sporadic illnesses known as neurodegenerative diseases are linked to gradual nervous system malfunction and neuronal death. Protein kinases are an increasingly popular class of pharmacological targets for disorders affecting ...
Dipanjan Karati, Dileep Kumar
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to determine whether early sensorimotor restriction (SMR) alters mitochondrial enzyme activities in rat muscles and brain structures. SMR was induced via immobilizing the hind limbs of pups for 16 h per day during the dark phase from birth to postnatal day (PND) 28.
Mélanie Van Gaever +4 more
wiley +1 more source