Results 111 to 120 of about 32,249 (223)

Protocol for producing brain-derived neurotrophic factor and neurotrophin-4 in their pro and active form in Escherichia coli

STAR Protocols
Summary: Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) are neurotrophic growth factors, signaling primarily via the tropomyosin receptor kinase B (TrkB).
Christoph Holzner, Katharina Böttinger, Christian G. Huber, Elfriede Dall, Hans Brandstetter   +4 more
doaj   +1 more source

Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.

PLoS Biology, 2018
The neurotrophin-3 (NT-3) receptor tropomyosin receptor kinase C (TrkC/NTRK3) has been described as a dependence receptor and, as such, triggers apoptosis in the absence of its ligand NT-3.
Marie Ménard, Clélia Costechareyre, Gabriel Ichim, Jonathan Blachier, David Neves, Loraine Jarrosson-Wuilleme, Reinhard Depping, Jan Koster, Pierre Saintigny, Patrick Mehlen, Servane Tauszig-Delamasure   +10 more
doaj   +1 more source

693. ESTROUS CYCLE-DEPENDENT EFFECTS OF A TROPOMYOSIN RECEPTOR KINASE B AGONIST ON FEAR EXTINCTION IN FEMALE ADOLESCENT RATS [PDF]

Int J Neuropsychopharmacol
Abstract Background Fear extinction, a laboratory model for exposure therapy, is modulated by endogenous levels of estradiol in adult female rodents and women, with extinction retention enhanced when extinction training occurs in a high-estradiol phase (e.g., proestrus) relative to a low-estradiol ...
Baker, K, Wang, Z, Gable, A, Richardson, R   +3 more
europepmc   +3 more sources

The link between sarcopenic obesity and Alzheimer's disease: a brain‐derived neurotrophic factor point of view

The Journal of Physiology, EarlyView.
Abstract figure legend A, Sarcopenic obesity is defined as the age‐related loss of skeletal muscle mass and function that often leads to the progression of comorbidities, such as Alzheimer's disease (AD). Though the exact link between the two diseases is unknown, alterations in brain‐derived neurotrophic factor (BDNF) may be a contributor.
Emily N. Copeland, Paul J. LeBlanc, Paula Duarte‐Guterman, Val A. Fajardo, Rebecca E. K. MacPherson   +4 more
wiley   +1 more source

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

Frontiers in Pharmacology, 2019
Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in ...
Amanda Thomaz, Amanda Thomaz, Kelly de Vargas Pinheiro, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Bárbara Kunzler Souza, Lauro Gregianin, Lauro Gregianin, Lauro Gregianin, Algemir L. Brunetto, Algemir L. Brunetto, André T. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Mariane da Cunha Jaeger, Vijay Ramaswamy, Vijay Ramaswamy, Carolina Nör, Carolina Nör, Michael D. Taylor, Michael D. Taylor, Michael D. Taylor, Michael D. Taylor, Michael D. Taylor, Rafael Roesler, Rafael Roesler   +27 more
doaj   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Arterial–venous differences of brain‐derived neurotrophic factor isoforms across the brain and muscle after exercise at different intensities

The Journal of Physiology, EarlyView.
Abstract figure legend Exercise‐induced increases in forearm venous plasma and serum brain‐derived neurotrophic factor (BDNF) are often assumed to be indicative of release from the brain. Sixteen healthy and physically fit adults (20–40 years old) were recruited to investigate whether exercise‐induced changes in forearm venous mature BDNF (mBDNF) and ...
Olga Tarassova, Yiwen Jiang, Helena Wallin, Mats Jensen‐Urstad, Nikola Drca, Julia Röja, Marjan Pontén, Abram Katz, Jonna Nilsson, Maria M. Ekblom, Marcus Moberg   +10 more
wiley   +1 more source

Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion [PDF]

, 2017
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions.
Cowman, Alan, Fleig, Andrea, Horgen, F. David, Malpede, Brian M, Nebl, Thomas, O\u27Neill, Joseph, Rogers, Kelly, Salinas, Nichole D, Sisquella, Xavier, Tham, Wai-Hong, Thompson, Jennifer K, Tolia, Niraj H, Whitehead, Lachlan   +12 more
core   +2 more sources

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, Volume 7, Issue 2, March 2026.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source

Targeting the NTSR2/TrkB oncogenic pathway in chronic lymphocytic leukemia

Scientific Reports
Current therapies that target the B-cell receptor pathway or the inhibition of anti-apoptotic proteins do not prevent the progressive forms of chronic lymphocytic leukemia (CLL), have low long-term efficacy and are subject to therapeutic resistance ...
Léa Ikhlef, May Yassine, Boutaîna Chandouri, Léa Rivière, Thomas Naves, Natalya Dmytruk, Nathalie Gachard, Marie-Odile Jauberteau, Paul-François Gallet   +8 more
doaj   +1 more source