Results 131 to 140 of about 32,249 (223)

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Regulation of a TrkB Alternative Transcript by microRNAs

Dementia and Geriatric Cognitive Disorders Extra, 2014
Background/Aims: Tropomyosin-related kinase B receptor (TrkB)-mediated signaling is vital for neuronal differentiation, survival, plasticity, and cognition.
Jenny Wong
doaj   +1 more source

ProteinDJ: A high‐performance and modular protein design pipeline

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Leveraging artificial intelligence and deep learning to generate proteins de novo (a.k.a. ‘synthetic proteins’) has unlocked new frontiers of protein design. Deep learning models trained on protein structures can generate novel protein designs that explore structural landscapes unseen by evolution.
Dylan Silke, Julie Iskander, Junqi Pan, Andrew P. Thompson, Anthony T. Papenfuss, Isabelle S. Lucet, Joshua M. Hardy   +6 more
wiley   +1 more source

Integrated multi‐omics analysis reveals metabolic reprogramming as a key driver of angiotensin II‐induced vascular remodeling

VIEW, Volume 7, Issue 1, February 2026.
This study investigates the molecular alterations underlying angiotensin II (Ang II)‐induced vascular remodeling in cardiovascular diseases using a multi‐omics approach. Through data exploration and integrated multi‐omics analysis, our findings reveal that Ang II‐driven vascular injury in vascular smooth muscle cells is mediated by metabolic ...
Yiwei Hu, Dan Zhao, Lingyan Zhong, Jianxujie Zheng, Dongxue Zhang, Enhui Wu, Qian Shi, Liang Qiao, Ling Lin   +8 more
wiley   +1 more source

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging

Pharmaceuticals, 2019
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging.
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier   +17 more
doaj   +1 more source

Ks1, an epithelial cell-specific gene, responds to early signals of head formation in Hydra [PDF]

, 1994
As a molecular marker for head specification in Hydra, we have cloned an epithelial cell-specific gene which responds to early signals of head formation.
Bosch, Thomas C. G., David, Charles N., Salgado, Luis M., Weinziger, Ruth   +3 more
core  

Endogenous neurotrophins are required for the induction of GABAergic long-term potentiation in the neonatal rat hippocampus.

, 2005
International audienceIn the developing rat hippocampus, GABAergic synapses undergo a Ca2+-dependent long-term potentiation (LTP(GABA-A)); this form of synaptic plasticity is induced in CA3 pyramidal neurons by delivering repetitive depolarizing pulses ...
Ben-Ari, Yehezkel, Gaïarsa, Jean-Luc, Gubellini, Paolo   +2 more
core   +5 more sources

Sculptors of cerebellar fissures and their potential as therapeutic targets for cerebellar dysfunction

Frontiers in Cellular Neuroscience
The cerebellum plays an important role in both motor control and cognition. The cerebellar cortex is neuron-rich and composed of characteristic folia and fissures.
Chiu-Lun Shen, Yu-Young Tsai, Woan-Yuh Tarn   +2 more
doaj   +1 more source

Caveolin-1 Phosphorylation Is Essential for Axonal Growth of Human Neurons Derived From iPSCs. [PDF]

, 2019
Proper axonal growth and guidance is essential for neuron differentiation and development. Abnormal neuronal development due to genetic or epigenetic influences can contribute to neurological and mental disorders such as Down syndrome, Rett syndrome, and
Almenar-Queralt, Angels, DerMardirossian, Celine, Head, Brian P, Leem, Joseph, Patel, Hemal H, Patel, Piyush M, Roth, David M, Wang, Shanshan, Zhang, Zheng   +8 more
core   +1 more source

RGS14 (414)-mediated prevention of an episodic memory loss: a study of molecular mechanism [PDF]

, 2015
A large proportion of human populations suffer memory impairments either caused by normal aging or afflicted by diverse neurological and neurodegenerative diseases. Memory enhancers and other drugs tested so far against memory loss have failed to produce
Navarro Lobato, Irene
core   +1 more source