Results 181 to 190 of about 32,249 (223)

Discovery of a Proteolysis Targeting Chimera for TRKA and RET-derived oncoproteins. [PDF]

Sci Rep
Moccia M, Zhang L, Wang Z, Wang M, Federico G, Santoro M, Li HY, Carlomagno F.   +7 more
europepmc   +1 more source

Optogenetic engineering of synthetic and natural receptors: design principles, functional mechanisms and biomedical applications. [PDF]

Regen Biomater
Zhao J, Chen Y, Gao B, Zhang L, Gao N, Hao S, Gao Z, Cai W, Yang J, Yang G.   +9 more
europepmc   +1 more source

Effects of exercise on tropomyosin-related kinase B receptor isoforms and ligands in skeletal muscle

, 2007
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Identification of potential inhibitors of tropomyosin receptor kinase B targeting CNS-related disorders and cancers

Journal of Biomolecular Structure and Dynamics, 2023
Tropomyosin receptor kinase B (TrkB), also known as neurotrophic tyrosine kinase receptor type 2 (NTRK2), is a protein that belongs to the family of receptor tyrosine kinases (RTKs). NTRK2 plays a crucial role in regulating the development and maturation of the central nervous system (CNS) and peripheral nervous system (PNS).
Mohammed Ageeli, Hakami, Bader S, Alotaibi, Ali, Hazazi, Alaa, Shafie, Ahad Amer, Alsaiari, Amal Adnan, Ashour, Farah, Anjum   +6 more
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Role of Tropomyosin-related kinase B receptor and brain-derived neurotrophic factor in cancer

Cytokine, 2020
The tropomyosin-related kinase B (TrkB) receptor is a member of the neurotrophic tyrosine kinase receptors family and, together with the brain-derived neurotrophic factor (BDNF), plays an important role in the development of breast cancer, lung cancer, neuroblastoma, colorectal cancer, leukemia, cervical cancer, gallbladder cancer, gastric cancer ...
Vilson, Serafim Junior, Glaucia Maria de Mendonça, Fernandes, Juliana Garcia de, Oliveira-Cucolo, Erika Cristina, Pavarino, Eny Maria, Goloni-Bertollo   +4 more
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Sexual motivation in male rats is modulated by tropomyosin receptor kinase B (TrkB).

Behavioral Neuroscience, 2019
The expression of brain derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) are regulated by gonadal hormone signaling and are expressed in brain areas that are important for sexual behaviors. Accordingly, BDNF and TrkB signaling have been shown to be important for the expression of consummatory sexual behaviors.
Wayne R, Hawley, Deandra E, Mosura
openaire   +2 more sources

Neurotrophic receptor, tropomyosin‐related kinase B as an independent prognostic marker in gastric cancer patients

Journal of Surgical Oncology, 2009
AbstractBackground and ObjectivesNeurotrophic receptor tyrosine kinase TrkB has been associated with clinical outcome and chemotherapy resistance in neuroblastoma and certain human malignancies. Recent studies have focused on the association between metastatic potential and TrkB expression in tumor cells.MethodsTo determine the role of TrkB in gastric ...
Koji, Tanaka, Yasuhiko, Mohri, Junji, Nishioka, Minako, Kobayashi, Masaki, Ohi, Chikao, Miki, Hitoshi, Tonouchi, Tsutomu, Nobori, Masato, Kusunoki   +8 more
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Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma

Human Pathology, 2013
Members of the tropomyosin receptor kinase (Trk) family have a high affinity for neurotrophins and regulate neuronal survival. The role of Trks in cancer is still controversial. The expression and role of TrkB and TrkC were examined in colorectal cancer (CRC). Immunohistochemical analysis of TrkB and TrkC was performed in 133 patients with CRC.
Tomonori, Sasahira, Nobuhiro, Ueda, Miyako, Kurihara, Sayako, Matsushima, Hitoshi, Ohmori, Kiyomu, Fujii, Ujjal K, Bhawal, Kazuhiko, Yamamoto, Tadaaki, Kirita, Hiroki, Kuniyasu   +9 more
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Spinal Activation of Tropomyosin Receptor Kinase-B Recovers the Impaired Endogenous Analgesia in Neuropathic Pain Rats

Anesthesia & Analgesia, 2019
BACKGROUND: Although endogenous analgesia plays an important role in controlling pain states, chronic pain patients exhibit decreased endogenous analgesia compared to healthy individuals. In rats, noxious stimulus–induced analgesia (NSIA), which is an indicator of endogenous analgesia, diminished 6 weeks after spinal nerve ...
Daiki, Kato, Takashi, Suto, Hideaki, Obata, Shigeru, Saito   +3 more
openaire   +2 more sources