Results 11 to 20 of about 32,170 (162)

Pharmacological Enhancement of Extinction Retention in Non-stressed Adolescent Rats but Not Those Exposed to Chronic Corticosterone

Frontiers in Neuroscience, 2022
Individuals exposed to chronic adverse experiences in childhood and adolescence are at increased risk of developing neuropsychiatric illnesses such as mood and anxiety disorders. Symptoms of anxiety disorders can often be reduced through exposure therapy,
Anthea A. Stylianakis, Kathryn D. Baker, Rick Richardson   +2 more
doaj   +1 more source

A kinase-deficient NTRK2 splice variant predominates in glioma and amplifies several oncogenic signaling pathways

Nature Communications, 2020
Tropomyosin receptor kinase B (TrkB), encoded by the neurotrophic tyrosine receptor kinase 2 (NTRK2) gene, exhibits intricate splicing patterns and post-translational modifications.
Siobhan S. Pattwell, Sonali Arora, Patrick J. Cimino, Tatsuya Ozawa, Frank Szulzewsky, Pia Hoellerbauer, Tobias Bonifert, Benjamin G. Hoffstrom, Norman E. Boiani, Hamid Bolouri, Colin E. Correnti, Barbara Oldrini, John R. Silber, Massimo Squatrito, Patrick J. Paddison, Eric C. Holland   +15 more
doaj   +1 more source

Molecular mechanisms of esophageal epithelial regeneration following repair of surgical defects with acellular silk fibroin grafts

Scientific Reports, 2021
Constructive remodeling of focal esophageal defects with biodegradable acellular grafts relies on the ability of host progenitor cell populations to repopulate implant regions and facilitate growth of de novo functional tissue.
Gokhan Gundogdu, Mehmet Tosun, Duncan Morhardt, Ali Hashemi Gheinani, Khalid Algarrahi, Xuehui Yang, Kyle Costa, Cinthia Galvez Alegria, Rosalyn M. Adam, Wei Yang, Joshua R. Mauney   +10 more
doaj   +1 more source

Brain‐Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Brain‐derived neurotrophic factor (BDNF) is expressed in neuronal and nonneuronal cells and may affect vascular functions via its receptor, tropomyosin‐related kinase B (TrkB).
Sarah Zierold, Katja Buschmann, Sogol Gachkar, Magdalena L. Bochenek, David Velmeden, Lukas Hobohm, Christian‐Friedrich Vahl, Katrin Schäfer   +7 more
doaj   +1 more source

Perirhinal Cortex LTP Does Not Require Astrocyte BDNF-TrkB Signaling

Cells, 2022
Neurons release and respond to brain-derived neurotrophic factor (BDNF) with bursts of brain activity. BDNF action is known to extend to peri-synaptic astrocytes, contributing to synaptic strengthening.
Beatrice Vignoli, Marco Canossa
doaj   +1 more source

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

SORLA-mediated trafficking of TrkB enhances the response of neurons to BDNF. [PDF]

PLoS ONE, 2013
Stimulation of neurons with brain-derived neurotrophic factor (BDNF) results in robust induction of SORLA, an intracellular sorting receptor of the VPS10P domain receptor gene family.
Michael Rohe, Daniela Hartl, Anja Nawarecki Fjorback, Joachim Klose, Thomas E Willnow   +4 more
doaj   +1 more source

Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus [PDF]

, 2011
Caldesmon (CaD) is an important actin modulator that associates with actin filaments to regulate cell morphology and motility. Although extensively studied in cultured cells, there is little functional information regarding the role of CaD in migrating ...
Bronner-Fraser, Marianne, Kee, Yun, Nie, Shuyi   +2 more
core   +2 more sources

Lower Serum Tropomyosin Receptor Kinase B Levels in Patients with Schizophrenia

Biomedical Journal, 2013
ackground: Brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) have previously been found to be reduced in the prefrontal cortex of patients with schizophrenia.
Yi-Yung Hung, Tiao-Lai Huang
doaj   +1 more source

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons

Neurobiology of Disease, 2018
Post-traumatic epilepsy is one of the most common and difficult to treat forms of acquired epilepsy worldwide. Currently, there is no effective way to prevent post-traumatic epileptogenesis.
Feng Gu, Isabel Parada, Tao Yang, Frank M. Longo, David A. Prince   +4 more
doaj   +1 more source