Results 21 to 30 of about 32,249 (223)

Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist. [PDF]

Exp Neurol, 2016
Brain radiotherapy is frequently used successfully to treat brain tumors. However, radiotherapy is often associated with declines in short-term and long-term memory, learning ability, and verbal fluency. We previously identified a downregulation of the brain-derived neurotrophic factor (BDNF) following cranial irradiation in experimental animals.
Yang P, Leu D, Ye K, Srinivasan C, Fike JR, Huang TT.   +5 more
europepmc   +4 more sources

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers

Acta Pharmaceutica Sinica B, 2021
Tropomyosin receptor kinase A, B and C (TRKA, TRKB and TRKC), which are well-known members of the cell surface receptor tyrosine kinase (RTK) family, are encoded by the neurotrophic receptor tyrosine kinase 1, 2 and 3 (NTRK1, NTRK2 and NTRK3) genes ...
Tingting Jiang, Guan Wang, Yao Liu, Lu Feng, Meng Wang, Jie Liu, Yi Chen, Liang Ouyang   +7 more
doaj   +1 more source

Serotonin Receptor 5-HT_2A Regulates TrkB Receptor Function in Heteroreceptor Complexes

Cells, 2022
Serotonin receptor 5-HT2A and tropomyosin receptor kinase B (TrkB) strongly contribute to neuroplasticity regulation and are implicated in numerous neuronal disorders.
Tatiana Ilchibaeva, Anton Tsybko, Andre Zeug, Franziska E. Müller, Daria Guseva, Stephan Bischoff, Evgeni Ponimaskin, Vladimir Naumenko   +7 more
doaj   +1 more source

Oral squamous cell carcinoma-released brain-derived neurotrophic factor contributes to oral cancer pain by peripheral tropomyosin receptor kinase B activation. [PDF]

Pain, 2022
Abstract Oral cancer pain is debilitating and understanding mechanisms for it is critical to develop novel treatment strategies treatment strategies. Brain-derived neurotrophic factor (BDNF) signaling is elevated in oral tumor biopsies and is involved with tumor progression.
Grayson M, Arris D, Wu P, Merlo J, Ibrahim T, Fang-Mei C, Valenzuela V, Ganatra S, Ruparel S.   +8 more
europepmc   +3 more sources

The role of brain derived neurotrophic factor in central nervous system

Frontiers in Aging Neuroscience, 2022
Brain derived neurotrophic factor (BDNF) has multiple biological functions which are mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor and the p75 neurotrophin receptor, involving in physiological and pathological
Yiyi Li, Yiyi Li, Fang Li, Fang Li, Dongdong Qin, Dongdong Qin, Hongyu Chen, Hongyu Chen, Jianhao Wang, Jianhao Wang, Jiabei Wang, Jiabei Wang, Shafei Song, Shafei Song, Chao Wang, Chao Wang, Yamei Wang, Yamei Wang, Songyan Liu, Songyan Liu, Dandan Gao, Dandan Gao, Zhi-Hao Wang, Zhi-Hao Wang   +23 more
doaj   +1 more source

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I. [PDF]

, 2016
BackgroundCardiovascular disease, a progressive manifestation of α-L-iduronidase deficiency or mucopolysaccharidosis type I, continues in patients both untreated and treated with hematopoietic stem cell transplantation or intravenous enzyme replacement ...
Dickson, Patricia I, Ellinwood, N Matthew, Esko, Jeffrey D, Gordts, Philip L, Khalid, Omar, Schwartz, Philip H, Vera, Moin U, Wang, Raymond Y   +7 more
core   +8 more sources

Promoting neurogenesis in hippocampal dentate gyrus of chronic unpredictable stress-induced depressive-like rats with paeoniflorin [PDF]

Journal of Integrative Neuroscience, 2019
Hippocampal neurogenesis plays an important role in the onset and treatment of depressive disorders. Previous studies suggest that paeoniflorin could be used as an antidepressant for treating rats subjected to chronic unpredictable stress. In this study,
Li-Bing Chen, Feng-Mei Qiu, Xiao-Ming Zhong, Cheng Hong, Zhen Huang
doaj   +1 more source

Postsurgical tactile-evoked pain: a role for brain-derived neurotrophic factor-tropomyosin receptor kinase B-dependent novel tactile corpuscles. [PDF]

Pain Rep
Abstract Introduction: Millions of people undergo surgical procedures each year with many developing postsurgical pain. Dynamic allodynia can arise when, for example, clothing brushing close to the surgical site elicits pain. The allodynia circuits that enable crosstalk between afferent tactile inputs and central pain
Wilson K, Sze Y, Regan A, Zhu C, Mazur K, Velichkova AN, Torsney C.   +6 more
europepmc   +4 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases. [PDF]

FEBS Open Bio
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Enkavi G.
europepmc   +2 more sources

Auditory deprivation modifies the expression of brain-derived neurotrophic factor and tropomyosin receptor kinase B in the rat auditory cortex. [PDF]

J Otol, 2017
The development and plasticity of central auditory system can be influenced by the change of peripheral neuronal activity. However, the molecular mechanism participating in the process remains elusive. Brain-derived neurotrophic factor (BDNF) binding with its functional receptor tropomyosin receptor kinase B (TrkB) has multiple effects on neurons. Here
Wang Y, Xu O, Liu Y, Lu H.
europepmc   +4 more sources