Results 31 to 40 of about 32,249 (223)

Fisetin provides antidepressant effects by activating the tropomyosin receptor kinase B signal pathway in mice [PDF]

Journal of Neurochemistry, 2017
AbstractDepression has been associated with a low‐grade chronic inflammatory state, suggesting a potential therapeutic role for anti‐inflammatory agents. Fisetin is a naturally occurring flavonoid in strawberries that has anti‐inflammatory activities, but whether fisetin has antidepressant effects is unknown.
Yamin Wang, Bin Wang, Jiaqi Lu, Haixia Shi, Siyi Gong, Yufan Wang, Ronald C. Hamdy, Balvin H. L. Chua, Lingli Yang, Xingshun Xu   +9 more
openaire   +3 more sources

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Journal of Visualized Experiments, 2022
Chemicals synthesized by plants, fungi, bacteria, and marine invertebrates have been a rich source of new drug hits and leads. Medicines such as statins, penicillin, paclitaxel, rapamycin, or artemisinin, commonly used in medical practice, have been first identified and isolated from natural products.
Arituluk, Zekiye Ceren, Adhikari, Bishnu, Maitra, Urmila, Goodman, Caroline, Ciesla, Lukasz M.   +4 more
openaire   +3 more sources

Yizhi Qingxin Formula Extract Ameliorates Cognitive Decline in Aged Rats via the Brain-Derived Neurotrophic Factor/Tropomyosin Receptor Kinase B Pathway. [PDF]

Front Pharmacol, 2020
Cognitive impairment and decline in old age are primarily driven by the accumulation of age-related neuropathologies, and old age is thus the primary risk factor for neurodegenerative diseases such as AD. Here, we investigated the effects of Yizhi Qingxin formula (YQF) extract on cognitive impairment in aged rats and determine the role of the brain ...
Ma L, Cao Y, Wang F, Li Z, Wang Z, Yang Y, Pei H, Li H.   +7 more
europepmc   +4 more sources

Tropomyosin-related receptor kinase B at the invasive front and tumour cell dedifferentiation in gastric cancer [PDF]

British Journal of Cancer, 2014
Tropomyosin-related receptor kinase B (TrkB) promotes proliferation and invasion, relating to poor prognosis of various malignancies. We examined the role of TrkB at the invasive front of gastric cancer (GC) and its association with tumour cell dedifferentiation and tumour budding.Immunoreactive TrkB was evaluated at the tumour centre and margin using ...
Tanaka, K, Shimura, T, Kitajima, T, Kondo, S, Ide, S, Okugawa, Y, Saigusa, S, Toiyama, Y, Inoue, Y, Araki, T, Uchida, K, Mohri, Y, Kusunoki, M   +12 more
openaire   +2 more sources

A tropomyosin receptor kinase family protein, NTRK2 is a potential predictive biomarker for lung adenocarcinoma [PDF]

PeerJ, 2019
Neurotrophic receptor tyrosine kinase 2 (NTRK2) is a member of the tropomyosin receptor kinase family associated with the tumor development. However, the detailed function of NTRK2 in lung cancer, especially in lung adenocarcinoma (LUAD), is still not ...
Xiang Wang, Zhijie Xu, Xi Chen, Xinxin Ren, Jie Wei, Shuyi Zhou, Xue Yang, Shuangshuang Zeng, Long Qian, Geting Wu, Zhicheng Gong, Yuanliang Yan   +11 more
doaj   +2 more sources

Antidepressant-like Effects of BDNF and NGF Individual Loop Dipeptide Mimetics Depend on the Signal Transmission Patterns Associated with Trk

Pharmaceuticals, 2022
Neurotrophins are considered as an attractive target for the development of antidepressants with a novel mechanism of action. Previously, the dimeric dipeptide mimetics of individual loops of nerve growth factor, NGF (GK-6, loop 1; GK-2, loop 4) and ...
Armen G. Mezhlumyan, Anna V. Tallerova, Polina Y. Povarnina, Aleksey V. Tarasiuk, Nellya M. Sazonova, Tatiana A. Gudasheva, Sergey B. Seredenin   +6 more
doaj   +1 more source

Non-Aβ-dependent factors associated with global cognitive and physical function in alzheimer's disease: a pilot multivariate analysis [PDF]

, 2019
Recent literature highlights the importance of identifying factors associated with mild cognitive impairment (MCI) and Alzheimer's Disease (AD).
Di Baldassarre, Angela, Fonte, Cristina, Galazzo, Ilaria Boscolo, Ghinassi, Barbara, Muti, Ettore, Naro, Fabio, Pedrinolla, Anna, Pizzini, Francesca Benedetta, Rende, Mario, Schena, Federico, Smania, Nicola, Stabile, Anna Maria, Tamburin, Stefano, Venneri, Mary Anna, Venturelli, Massimo   +14 more
core   +2 more sources

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

The Emerging Role of BDNF/TrkB Signaling in Cardiovascular Diseases

Life, 2021
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the central nervous system. Numerous studies suggest that BDNF has extensive roles by binding to its specific receptor, tropomyosin-related kinase receptor B (TrkB ...
Peng-Zhou Hang, Hua Zhu, Pei-Feng Li, Jie Liu, Feng-Qin Ge, Jing Zhao, Zhi-Min Du   +6 more
doaj   +1 more source

A genomic analysis and transcriptomic atlas of gene expression in Psoroptes ovis reveals feeding- and stage-specific patterns of allergen expression [PDF]

, 2019
Background: Psoroptic mange, caused by infestation with the ectoparasitic mite, Psoroptes ovis, is highly contagious, resulting in intense pruritus and represents a major welfare and economic concern for the livestock industry Worldwide.
Bartley, Kathryn, Burgess, Stewart TG, Down, Rachel E, Dunn, Jackie, Marr, Edward J, Nisbet, Alasdair J, Nunn, Francesca G, Prickett, Jessica C, Rombauts, Stephane, Van de Peer, Yves, Van Leeuwen, Thomas, Weaver, Robert J   +11 more
core   +2 more sources