Results 81 to 90 of about 32,249 (223)

Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2) Alterations in Low-Grade Gliomas: Report of a Novel Gene Fusion Partner in a Pilocytic Astrocytoma and Review of the Literature

Case Reports in Pathology, 2020
Pilocytic astrocytoma is a low-grade glial neoplasm of the central nervous system (CNS) that tends to occur in the pediatric population and less commonly presents in adults.
Siobhan S. Pattwell, Eric Q. Konnick, Yajuan J. Liu, Rebecca A. Yoda, Laligam N. Sekhar, Patrick J. Cimino   +5 more
doaj   +1 more source

Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. [PDF]

J Biol Chem, 2014
Neuronal protein-tyrosine phosphatase 1B (PTP1B) deficiency in mice results in enhanced leptin signaling and protection from diet-induced obesity; however, whether additional signaling pathways in the brain contribute to the metabolic effects of PTP1B deficiency remains unclear.
Ozek C, Kanoski SE, Zhang ZY, Grill HJ, Bence KK.   +4 more
europepmc   +4 more sources

Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis [PDF]

, 2016
Background: Inflammation is an essential component of arthritis pain. Nerve growth factor (NGF) plays a key role in acute and chronic pain states especially those associated with inflammation. NGF acts through tropomyosin-receptor-kinase A (TrkA).
A Bendele, A Bendele, AK Suokas, AM Bendele, B Nico, BG Petty, C Barthel, CD Dijkstra, CJ Woolf, CM Pearson, CS Bonnet, D Male, DA Walsh, DA Walsh, DA Walsh, DA Walsh, David A. Walsh, DL Shelton, DN Benslay, DR Sagar, G Schett, GR Lewin, HC Seegers, HG Schaible, Jed Pheneger, JR Ghilardi, JR Ghilardi, JR Ghilardi, Karyn S. Bouhana, KE McNamee, KM Mearow, KS Williams, L Aloe, L Aloe, L Djouhri, L Manni, LA Stoppiello, LN Nwosu, M Koltzenburg, NE Lane, NH Waseem, P Sanga, PI Mapp, PI Mapp, PI Mapp, PJ Tiseo, PP Sanna, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Ashraf, S Suri, Sadaf Ashraf, SB McMahon, Steven W. Andrews, TJ Coderre, WO Cooper   +57 more
core   +4 more sources

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Potential novel therapy targets in neuroendocrine carcinomas of the breast [PDF]

, 2018
Neuroendocrine carcinoma (NEC) of the breast is a rare, special type of breast cancer, reportedly constituting 2% to 5% of all breast cancers. Although breast NEC does not have a specific targeted therapy, several new targeted therapies based on specific
Contreras, Elma, Florento, Elena, Gatalica, Zoran, Palazzo, Juan, Sanati, Souzan, Swensen, Jeffrey, Vranic, Semir, Xiu, Joanne   +7 more
core   +2 more sources

Underlying Mechanisms of the Treatment Efficacy of (R, S)‐Ketamine for Post‐Traumatic Stress Disorder and Depression: A Review

Medicine Advances, EarlyView.
Research shows that (R, S)‐ketamine and its stereoisomers effectively reduce symptoms of post‐traumatic stress disorder (PTSD) and treatment‐resistant depression, with (R)‐ketamine offering similar benefits with fewer side effects. Evidence highlights specific neural circuits and regions, including the dentate gyrus, prefrontal cortex, vCA3, dorsal ...
Thomas Edward Cutting, Richard Evans Hartman   +1 more
wiley   +1 more source

Anti-Food allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK [PDF]

, 2016
Polysaccharides from Gracilaria lemaneiformis in particular possess various bioactive functions, but their antiallergic activity remains incompletely defined.
Chao-Lan Shi, Guang-Ming Liu, Lee A. J., Marcos Alcocer, Min-Jie Cao, Qing-Mei Liu, Sha-Sha Xu, Shevach E. M., Soheila J. Maleki, Yang Yang   +9 more
core   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Translating Systems Medicine Into Clinical Practice: Examples From Pulmonary Medicine With Genetic Disorders, Infections, Inflammations, Cancer Genesis, and Treatment Implication of Molecular Alterations in Non-small-cell Lung Cancers and Personalized Medicine

Frontiers in Medicine, 2019
Non-small-cell lung cancers (NSCLC) represent 85% of all lung cancers, with adenocarcinoma as the most common subtype. Since the 2000's, the discovery of molecular alterations including epidermal growth factor receptor (EGFR) mutations and anaplastic ...
Julian Pinsolle, Julian Pinsolle, Anne McLeer-Florin, Anne McLeer-Florin, Anne McLeer-Florin, Matteo Giaj Levra, Matteo Giaj Levra, Florence de Fraipont, Florence de Fraipont, Camille Emprou, Camille Emprou, Elisa Gobbini, Elisa Gobbini, Anne-Claire Toffart, Anne-Claire Toffart, Anne-Claire Toffart   +15 more
doaj   +1 more source

Molecular IgE Reactivity Profiling With Micro‐Arrayed Allergens Reveals Distinct Interregional Patterns of Sensitization and a Hypoallergenic Region in Türkiye

Allergy, EarlyView.
A prospective, systematic and cross‐sectional population study was performed involving 1000 adult subjects from five centers representing different climatic areas of Türkiye (Turkey). Molecular IgE profiling demonstrated substantial interregional variation and identified a hypoallergenic region in the easternmost area with a continental climate.
Alp Kazancioglu, Huey‐Jy Huang, Sengul Aksakal, Ismet Bulut, Maria‐Roxana Buzan, Kuan‐Wei Chen, Monica Daniela Cotarcă, Alexandra Dubovets, Pia Gattinger, Okan Gulbahar, Ali Fuat Kalyoncu, Alexander Karaulov, Evgenii Kozlov, Carmen Panaitescu, Thomas Schlederer, Daria Trifonova, Mikhail Tulaev, Murat Turk, Susanne Vrtala, Milena Weber, Lauriana‐Eunice Zbîrcea, Bulent Enis Sekerel, Rudolf Valenta   +22 more
wiley   +1 more source