Results 211 to 220 of about 113,140 (309)

Mitochondrial peptide MOTS‐c suppresses systemic and cardiac inflammasome activation in a diabetic rat model

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) is associated with chronic systemic and cardiac inflammation, contributing to the development of diabetic cardiomyopathy. The mitochondrial‐derived peptide mitochondrial open reading frame of the 12S rRNA type‐C (MOTS‐c) has emerged as a promising regulator of metabolic and inflammatory pathways.
Aimee R. Mills, Antonio de Souza, Toan Pham, Odunayo O. Mugisho   +3 more
wiley   +1 more source

Effects of chemical myosin II cross‐bridge inhibitors on eccentric force production in skinned muscle fibres

Experimental Physiology, EarlyView.
Abstract Eccentric muscle contractions are essential for locomotion and daily activities. Force during these contractions depends on both cross‐bridge (XB) and non‐cross‐bridge (non‐XB) elements, including titin, with contributions varying by fibre type and contraction velocity.
André Tomalka, Sven Weidner, Christian Rode, Tobias Siebert   +3 more
wiley   +1 more source

Aptamer-Based Gold Nanoparticle Lateral Flow Assay for Rapid Detection of Cardiac Troponin I. [PDF]

Biosensors (Basel)
Zhang J, Pang J, Cui C.
europepmc   +1 more source

Advances in cardiac devices and bioelectronics augmented with artificial intelligence

The Journal of Physiology, EarlyView.
Abstract figure legend Interfaces between the human heart, diagnostic bioelectronics, artificial intelligence, and clinical care. From left to right: Human heart and biosensor interface; representative waveforms of common diagnostic bioelectronic sensing modalities.
Charles Stark, Eric Rytkin, Andrei Alexandru Mircea, Igor R. Efimov   +3 more
wiley   +1 more source

Targeting Troponin I Phosphorylation for Precision Treatment of Diastolic Dysfunction

Chao Y, McAndrew DJ, Revuelta D, Yadav R, Hong W, Hu J, Folkmanaite M, Valli E, Olmedilla MG, Koschinski A, Surdo NC, Tomek J, Edwards H, Blair C, Girdauskas E, Henderson D, Hurst J, Linekar A, Psaras Y, Gorelik J, Smart N, Toepfer C, Maddock H, Baillie G, Lygate CA, Molina CE, Zaccolo M.   +26 more
europepmc   +1 more source

High Sensitive Cardiac Troponin-I (Hs-cTnI) Levels in Asymptomatic Hemodialysis Patients. [PDF]

J Clin Med
Rabi O, Shavit L, Loutati R, Taha L, Karmi M, Brin A, Deeb D, Levi N, Fink N, Sabouret P, Manassra M, Qadan A, Amro M, Glikson M, Asher E.   +14 more
europepmc   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Determination of Cardiac Troponin I in Guinea Pigs (Cavia porcellus) under Different Restraint Methods and Using a Point-of-Care Assay or Laboratory Analyzer. [PDF]

J Am Assoc Lab Anim Sci
Day AL, Santangelo KS, Ozawa SM, Brandão J, Sadar MJ.   +4 more
europepmc   +1 more source

Elucidating the cellular determinants of the end‐systolic pressure‐volume relationship of the heart via computational modelling

The Journal of Physiology, EarlyView.
Abstract figure legend Using a multiscale computational model of left ventricular electromechanics, we investigated how sarcomere dynamics influence the end‐systolic pressure‐volume (ESPV) relationship in ejecting beats compared to isovolumetric beats.
Francesco Regazzoni, Corrado Poggesi, Cecilia Ferrantini   +2 more
wiley   +1 more source

Troponin I is an independent marker of cardiovascular mortality risk in chronic kidney disease patients. [PDF]

J Bras Nefrol
Romaniello G, Hayashi SY, Guerra BS, Riella MC, Lindholm B, Marques GL, Nascimento MMD.   +6 more
europepmc   +1 more source