Results 261 to 270 of about 113,140 (309)

The mobility of troponin C and troponin I in muscle

Journal of Molecular Recognition, 1997
In vertebrate skeletal muscle, contraction is initiated by the elevation of the intracellular Ca2+ concentration. The binding of Ca2+ to TnC induces a series of conformational changes which ultimately release the inhibition of the actomyosin ATPase activity by Tnl.
H C, Li, K, Hideg, P G, Fajer
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Defining the Region of Troponin-I that Binds to Troponin-C

Biochemistry, 1999
The kinetics and energetics of the binding of three troponin-I peptides, corresponding to regions 96-131 (TnI96-131), 96-139 (TnI96-139), and 96-148 (TnI96-148), to skeletal chicken troponin-C were investigated using multinuclear, multidimensional NMR spectroscopy.
R T, McKay, B P, Tripet, J R, Pearlstone, L B, Smillie, B D, Sykes   +4 more
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Troponin I

Pediatric Emergency Care, 2012
Elevated cardiac troponin I can occur in patients with cardiac injury or sepsis. However, extreme elevations of serum cardiac troponin I in pediatric patients without myocardial injury are rare. We present a case of a 14-year-old girl involved in a motor vehicle accident with muscle injury, who was readmitted with sepsis and severely elevated serum ...
Claudeen K F, Scott, William A, Suarez
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The binding sites of rabbit skeletal troponin-I on troponin-T

Canadian Journal of Biochemistry, 1980
Various fragments derived from rabbit skeletal muscle troponin-T (Tn-T) by chemical and (or) proteolytic cleavage were mixed with whole troponin-I (Tn-I) and applied to a Sephadex G-75 gel filtration column in order to determine the binding site of Tn-I on Tn-T. This site of interaction was found to span two distinct regions of Tn-T.
J R, Pearlstone, L B, Smillie
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Binding of Troponin I and the Troponin I−Troponin C Complex to Actin−Tropomyosin. Dissociation by Myosin Subfragment 1

Biochemistry, 2000
Troponin I (TnI) is the component of the troponin complex, TnI, TnC, TnT, that is responsible for inhibition of actomyosin ATPase activity. Using the fluorescence of pyrene-labeled tropomyosin (Tm), we probed the interaction of TnI and TnIC with Tm on the reconstituted muscle thin filament.
X, Zhou, E P, Morris, S S, Lehrer
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Modulation of Cardiac Troponin C−Cardiac Troponin I Regulatory Interactions by the Amino-terminus of Cardiac Troponin I

Biochemistry, 2001
Multidimensional heteronuclear magnetic resonance studies of the cardiac troponin C/troponin I(1-80)/troponin I(129-166) complex demonstrated that cardiac troponin I(129-166), corresponding to the adjacent inhibitory and regulatory regions, interacts with and induces an opening of the cardiac troponin C regulatory domain.
M B, Abbott, W J, Dong, A, Dvoretsky, B, DaGue, R M, Caprioli, H C, Cheung, P R, Rosevear   +6 more
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Structural and functional studies on Troponin I and Troponin C interactions

Journal of Cellular Biochemistry, 2001
AbstractTroponin I (TnI) peptides (TnI inhibitory peptide residues 104–115, Ip; TnI regulatory peptide resides 1–30, TnI1–30), recombinant Troponin C (TnC) and Troponin I mutants were used to study the structural and functional relationship between TnI and TnC.
S M, Ngai, J R, Pearlstone, C S, Farah, F C, Reinach, L B, Smillie, R S, Hodges   +5 more
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Cardiac Troponin I in Asphyxiated Neonates

Neonatology, 2006
<i>Background:</i> Cardiac troponins T (cTnT) and I (cTnI) are <i>well-established </i>markers in detecting myocardial ischemic damage in adults. Perinatal asphyxia is associated with cardiac dysfunction. <i>Objectives:</i> To evaluate serum concentrations of cTnI in asphyxiated neonates and to investigate whether ...
Trevisanuto D., Picco G., Golin R., Doglioni N., Altinier S., Zaninotto M., Zanardo V.   +6 more
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Troponin I: Inhibitor or facilitator

Molecular and Cellular Biochemistry, 1999
TN-I occurs as a homologous group of proteins which form part of the regulatory system of vertebrate and invertebrate striated muscle. These proteins are present in vertebrate muscle as isoforms, Mr 21000-24000, that are specific for the muscle type and under individual genetic control.
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Interaction of troponin I and troponin C: ¹⁹F NMR studies of the binding of the inhibitory troponin I peptide to turkey skeletal troponin C

Biochemistry and Cell Biology, 1991
We have used 19F nuclear magnetic resonance spectroscopy to study the interaction of the inhibitory region of troponin (TnI) with apo- and calcium(II)-saturated turkey skeletal troponin C (TnC), using the synthetic TnI analogue Nα-acetyl[19FPhe106]TnI(104–115)amide.
A P, Campbell, P J, Cachia, B D, Sykes
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