Results 61 to 70 of about 21,232,041 (300)

Troponin I and myocardial injury in the ICU

British Journal of Anaesthesia, 1999
Cardiac troponin I (cTnI) is a protein that is specific to heart muscle. Increased concentrations appear in serum after myocardial cell injury. cTnI was compared with creatinine kinase MB (CK MB), myoglobin and the 12-lead ECG for detection of myocardial injury in an unselected series of 109 medical and surgical ICU patients.
J S, Noble, A M, Reid, L V, Jordan, A C, Glen, J A, Davidson   +4 more
openaire   +2 more sources

Clinical evaluation of the ACS:180 cardiac troponin I assay

, 2001
All patients admitted to the coronary care unit with suspected acute coronary syndromes were evaluated by serial electrocardiography and blood draws on admission and at 4 and 12h from admission. Diagnosis was based on conventional WHO criteria.
Collinson, P.O., Wiggins, N., Gaze, D.C.
core   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Association Between Postoperative Troponin Levels and 90 Days Mortality Among Patients Undergoing Non-Cardiac Surgery

Pakistan Journal of Medicine and Dentistry
Background: Globally, the mortality of non-cardiac surgery patients within the first month is increasing. Monitoring troponin-I levels aids in early mortality risk identification.
Madiha Haroon, Areeba Abdullah, Faisal Siddiqi, Mirza Arshad Beg, Anum Arshad Beg   +4 more
doaj   +1 more source

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Assessment of cardiac troponin I in patients with pulmonary emboli and its relationship with right ventricular dysfunction

Journal of Mazandaran University of Medical Sciences, 2009
(Received 16 December, 2008; Accepted 27 May, 2009)AbstractBackground and purpose: Right ventricular dysfunction is common in major pulmonary embolisms. The purpose of this study was to evaluate the prevalence and diagnostic utility of cardiac troponin I
Sasan Tavana, Yunes Panahi, Nasrollah Saed Moucheshi, Fatemeh Beiraghdar, Ebrahim Naderi3Department of Internal Medicine, Faculty of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran, Shahram Ala, Rouhollah Habibey   +6 more
doaj  

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Cardiac troponin i in acute pericarditis

Journal of the American College of Cardiology, 2003
This study was designed to investigate the prognostic value of cardiac troponin I (cTnI) in viral or idiopathic pericarditis.Idiopathic acute pericarditis has been recently reported as a possible cause of nonischemic release of cTnI. The prognostic value of this observation remains unknown.We enrolled 118 consecutive cases (age 49.2 +/- 18.4 years; 61 ...
Imazio M, Demichelis B, Cecchi E, Belli R, Ghisio A, Bobbio M, Trinchero R   +6 more
openaire   +4 more sources

The Antidiabetic Potential of Alpha‐Mangostin: A Review of Preclinical and Clinical Evidence

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Alpha‐mangostin is a compound from the pericarp of Garcinia mangostana. The antidiabetic effects of alpha‐mangostin include enhancing insulin secretion, improving glucose uptake through GLUT receptor upregulation, reducing oxidative stress and inflammation, promoting wound healing, reducing HbA1C, reducing HOMA‐IR index, and decreased mRNA expressions ...
Oliver Dean John, Nur Damia Iwani Zulkiflee, Siti Raihanah Shafie, Ramlah George, Melonney Patrick   +4 more
wiley   +1 more source

Comparison of point-of-care and laboratory troponin I assays

Zdravniški Vestnik, 2011
BACKGROUND In recent years a number of pointof- care troponin assays have emerged. There have been reports of discrepancies between the results of point-of-care and laboratory assays.
Andrej Markota, Matej Bernhardt, Miroslav Palfy   +2 more
doaj