Results 131 to 140 of about 137,104 (231)

A Psychometric Evaluation of Maximum Phonation Time and S/Z Ratio as Pragmatic Outcome Measures of Bulbar Function in Adults With Spinal Muscular Atrophy

Muscle &Nerve, Volume 73, Issue 2, Page 297-303, February 2026.
ABSTRACT Introduction/Aims A pragmatic evaluation of bulbar function among adults with spinal muscular atrophy (awSMA) is needed, requiring the validation of a low‐cost, feasible outcome measure (OM). Maximum phonation time (MPT) and S/Z ratio (S/Z) are potential low‐cost OMs for bulbar function. This study aimed to evaluate the psychometric properties
Jeremy Slayter, Lauren Casey, Dorothy Drost, Shane McCullum, Allison Christie, Colleen O'Connell   +5 more
wiley   +1 more source

Pair‐Feeding Study Designs Can Create Biases and Inflate Type I Error Rates: A Simulation Study

Obesity, Volume 34, Issue 2, Page 407-416, February 2026.
ABSTRACT Objective Pair‐feeding is a study design element where one group's food intake is provided to another group to assess whether a treatment effect is independent of food intake. Investigators often assume equivalent food intake across experimental conditions and exclude it from the statistical analysis.
Wasiuddin Najam, Daniel E. Kpormegbey, Deependra K. Thapa, Bret Rust, Lilian Golzarri‐Arroyo, Lance H. Baumgard, Louis Wai‐Tong Fan, Joseph G. Ibrahim, Edith J. Mayorga, David B. Allison   +9 more
wiley   +1 more source

On‐Resin Pictet–Spengler Cyclization for 1,2,3,4‐Tetrahydro‐β‐carboline‐3‐carboxylate (Tcc) Peptide Synthesis With Acid‐Labile Functional Tolerance

Journal of Peptide Science, Volume 32, Issue 2, February 2026.
The constrained tryptophan (Trp) analog 1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (Tcc) is used to restrict peptide conformation in structure–activity relationship studies. Although Pictet–Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid‐labile functionality.
Omer S. L. N'dri, Charity D. Yongo‐Luwawa, Xiaozheng Wei, Kajumee Bora Bhowal, Chitra P. Sadanandhan, Darince Truong, Ida Boccino, Will Maclean, Lylia Dif‐Yaiche, Zoé Villeneuve, William D. Lubell   +10 more
wiley   +1 more source

A Model‐Based Meta‐Analysis of Pembrolizumab Effects on Patient‐Reported Quality of Life: Advancing Patient‐Centered Oncology Drug Development

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pembrolizumab is an immune checkpoint inhibitor that has been approved for more than 20 different indications and has shown great survival benefits in various types of cancer. However, the reported benefits of pembrolizumab in patients' quality of life (QoL) have been inconsistent across different studies and different types of cancer.
Yiqin Zou, Yimeng Sun, Sudhamshu Ravva, Lynne I. Wagner, Jiawei Zhou   +4 more
wiley   +1 more source

Model‐Based Meta‐Analysis With MonolixSuite: A Tutorial for Longitudinal Categorical and Continuous Data

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Model‐based meta‐analysis (MBMA) informs key drug development decisions by integrating data, published or unpublished, from multiple studies. Due to these various sources of information and the use of summary‐level data (e.g., mean responses over treatment arms or percent responders), MBMA models require careful implementation.
Chloe Bracis, Amit Taneja, Yassine Kamal Lyauk, Heather Barcomb, Amparo de la Peña, Géraldine Cellière   +5 more
wiley   +1 more source

Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley   +2 more sources

Testosterone Modulation of Muscle Transcriptomic Profile During Lifestyle Therapy in Older Men with Obesity and Hypogonadism

Journal of Cachexia, Sarcopenia and Muscle
Background Testosterone replacement therapy (TRT) added to lifestyle therapy can mitigate weight‐loss–induced reduction of muscle mass and bone mineral density (BMD) in older men with obesity and hypogonadism.
Viola Viola, Tagari Samanta, Maria Liza Duremdes Nava, Alessandra Celli, Reina Armamento‐Villareal, Ngoc Ho Lam Nguyen, Georgia Colleluori, Yoann Barnouin, Nicola Napoli, Clifford Qualls, Benny Abraham Kaipparettu, Dennis T. Villareal   +11 more
doaj   +1 more source

Kamu yayıncılığı ve TRT

, 2020
Kamu Hizmeti Yayıncılığı, `Halk için yapılan, halk tarafından finanse edilen ve halk tarafından kontrol edilen, bilgilendirmeyi, eğitmeyi ve eğlendirmeyi amaçlayan, ülkenin coğrafi olarak tümünü kapsamak ve ülkenin tüm kesimlerine yayın hizmeti götürme sorumluluğuna sahip yayıncılıktır?.Kamu hizmeti yayıncılığı kavramının geçmişi İngiliz Yayın Kurumu ...
openaire   +1 more source

Bayesian Network Meta‐Analysis With One or Two Continuous Outcomes Measured at Multiple Time Points Using Gaussian Random Walks With Drift

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Network meta‐analysis of randomized controlled trials is traditionally conducted on a single outcome measured at one time point. However, many trials also feature a secondary outcome and both outcomes may have been reported at multiple time points. Existing network meta‐analysis methods for synthesizing continuous outcome data from such trials
Pai‐Shan Cheng, Bruno R. da Costa, George Tomlinson   +2 more
wiley   +1 more source

Strategy to Control Biases in Prior Event Rate Ratio Method, With Application to Palliative Care in Patients With Advanced Cancer

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Prior event rate ratio (PERR) is a method shown to perform well in mitigating confounding and is gaining popularity in real‐world evidence research. However, it depends on several model assumptions. We propose an analytic strategy to correct biases arising from violation of two model assumptions, namely, population homogeneity and event ...
Xiangmei Ma, Grace Meijuan Yang, Qingyuan Zhuang, Yin Bun Cheung   +3 more
wiley   +1 more source