Results 131 to 140 of about 323,961 (279)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Approval of Trump Stable, Increases Among Core Constituencies 4/19/2019 [PDF]
, 2019 Four in ten New Hampshire residents approve of Donald Trump\u27s performance as President, largely unchanged over the past year. Approval of Trump has increased over the past year among core groups of supporters such as conservative radio listeners and ...
UNH Survey Center
core +1 more source
TREX1, a predator for treating MSI‐H tumors?
Molecular Oncology, EarlyView.Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Frames and Triggers of Extreme Speech: The Case of Transphobia
Social InclusionThis research explores, from a critical discourse perspective, the following questions: What frames are used to construct transphobic argumentation and its counterargumentation? What triggers the discriminatory comments?
Fabienne Baider
doaj +1 more source
No, Education Isn\u27t the Civil Rights Issue of Our Time
, 2017 George W. Bush said it as he warned us about the soft bigotry of low expectations. Barack Obama said it. So did Mitt Romney, Arne Duncan, and John McCain. And now Donald Trump is saying it, too. In his first joint-session address to Congress, President
Powell, Dave
core
As the Trump administration retreats on climate change, US cities are moving forward [PDF]
, 2018 This article was originally published in "The Conversation" on February 20, 2018. Read the original article here: https://theconversation.com/as-the-trump-administration-retreats-on-climate-change-us-cities-are-moving-forward-91612https://theconversation.
Einstein, Katherine Levine +2 more
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Home Stretch: Trump Keeps Lead 2/7/16 [PDF]
, 2016 With only days remaining, Donald Trump still holds the lead in the New Hampshire Primary race and most Republican voters think he will win the primary.
Survey Center, UNH
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source