Results 61 to 70 of about 330,573 (298)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Trump Still On Top In NH, Big Battle For Second, Most Voters Still Undecided 1/20/16 [PDF]
, 2016 Donald Trump has maintained his double digit lead in the New Hampshire Primary race while the rest of the field remains tightly packed. However, Trump continues to be the candidate that New Hampshire Republicans say they are least likely to vote for ...
Survey Center, UNH
core +1 more source
(Trade)mark America Great Again: Should Political Slogans Be Able to Receive Trademark Protection? [PDF]
, 2020 In late 2016, Donald Trump was granted trademark protection for his presidential campaign slogan, “Make America Great Again.” This registration is one of few—if not the only—political slogans registered as a trademark with the USPTO.
Kerrick, Katherine
core +1 more source
EMBO reports, 2017 On January 27, US President Donald Trump made good on one of his campaign promises and issued an executive order that bars citizens from seven countries from entering the USA for 90 days. It also suspends the admission of all refugees for 120 days, nominally “to protect the American people from terrorist attacks by foreign nationals admitted to the ...
Holger Breithaupt, Bernd Pulverer
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Jurisdiction in the Trump Era [PDF]
, 2018 The election of Donald Trump as President of the United States induced immediate speculation about how his tenure would affect various areas of the law.
Dodson, Scott
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Approval of Trump On the Rise in NH; Residents Support Mueller Investigation 4/23/18 [PDF]
, 2018 New Hampshire residents have become somewhat more positive in their assessment of Donald Trump\u27s performance as president. Approval of his overall job performance, handling of the economy and foreign affairs, and his personal favorability have all ...
Survey Center, UNH
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source