Results 101 to 110 of about 352,001 (326)

A key variant in the cis-regulatory element of flowering gene Ghd8 associated with cold tolerance in rice. [PDF]

, 2019
Variations in the gene promoter play critical roles in the evolution of important adaptive traits in crops, but direct links of the regulatory mutation to the adaptive change are not well understood.
Fan, Kai, Gong, Rong, Wang, Peng, Xiong, Yin, Yang, Ying, Yu, Sibin   +5 more
core  

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A Novel Multiple Dependent State Sampling Plan Based on Time Truncated Life Tests Using Mean Lifetime [PDF]

, 2022
Pramote Charongrattanasakul, Wimonmas Bamrungsetthapong, Poom Kumam   +2 more
openalex   +1 more source

The Stargazin-Related Protein {gamma}7 Interacts with the mRNA-Binding Protein Heterogeneous Nuclear Ribonucleoprotein A2 and Regulates the Stability of Specific mRNAs, Including CaV2.2 [PDF]

, 2008
The role(s) of the novel stargazin-like {gamma}-subunit proteins remain controversial. We have shown previously that the neuron-specific {gamma}7 suppresses the expression of certain calcium channels, particularly CaV2.2, and is therefore unlikely to ...
Bolsover, Steven, Butcher, Adrian J., Cox, David J., Davies, Anthony, Dolphin, Annette C., Ferron, Laurent, Leroy, Jerôme, Moss, Fraser J., Page, Karen M., Pratt, Wendy S., Sellaturay, Priya, Waithe, Dominic   +11 more
core   +1 more source

Randomized Reference Classifier with Gaussian Distribution and Soft Confusion Matrix Applied to the Improving Weak Classifiers

, 2019
In this paper, an issue of building the RRC model using probability distributions other than beta distribution is addressed. More precisely, in this paper, we propose to build the RRR model using the truncated normal distribution.
B. Bergmann, D Yekutieli, DJ Hand, F Provost, F Wilcoxon, HA David, J Demšar, James O. Berger, JR Quinlan, L Breiman, L Kuncheva, M Friedman, M Hall, M Kurzynski, Marcin Majak, Marek Kurzynski, Marina Sokolova, N Johnson, Pawel Trajdos, R Lysiak, S Garcia, T Cover, T Woloszynski, Y Freund   +23 more
core   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

BAYESIAN ESTIMATION OF GENERALIZED EXPONENTIAL DISTRIBUTION WITH MULTIPLE CHANGE POINTS FOR TRUNCATED AND CENSORED DATA

Jixie qiangdu, 2016
The complete-data likelihood function of generalized exponential distribution for truncated and censored data is obtained by filling in the missing data of the life variable using rejection method.
HE ChaoBing
doaj