Results 121 to 130 of about 352,001 (326)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Reliability assessment of products with Weibull lifetimes: A two-sided linked lots deferred sampling plan (T-SLLDSP)

Scientific African
This study proposes the Two-Sided Linked Lots Deferred Sampling Plan (T-SLLDSP), a novel statistical quality control method for assessing product reliability when lifetimes follow a Weibull distribution under time-truncated inspection, thus establishing ...
Joseph Odunayo Braimah, Fabio Mathias Correa   +1 more
doaj   +1 more source

Acceptance Sampling Plans with Truncated Life Tests for the Length-biased Weighted Lomax Distribution [PDF]

, 2021
Amer Ibrahim Al‐Omari, Ibrahim M. Almanjahie, Olena Kravchuk   +2 more
openalex   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Robust and parallel scalable iterative solutions for large-scale finite cell analyses

, 2018
The finite cell method is a highly flexible discretization technique for numerical analysis on domains with complex geometries. By using a non-boundary conforming computational domain that can be easily meshed, automatized computations on a wide range of
D'Angella, Davide, de Prenter, Frits, Elhaddad, Mohamed, Jomo, John N., Kirschke, Jan S., Kollmannsberger, Stefan, Nübel, Vera, Rank, Ernst, van Brummelen, Harald, Verhoosel, Clemens V.   +9 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Designing of multiple dependent state sampling plan for Exponentiated Frechet Distribution

Research in Statistics
An approach for making decisions regarding the lot being inspected is acceptance sampling. A decision regarding the entire lot under inspection is made based on a representative sample.
Gadde Srinivasa Rao, Sd. Jilani, Josephat Kirigiti Peter   +2 more
doaj   +1 more source

Hover performance tests of baseline metal and Advanced Technology Blade (ATB) rotor systems for the XV-15 tilt rotor aircraft [PDF]

Rotor hover performance data were obtained for two full-scale rotor systems designed for the XV-15 Tilt Rotor Research Aircraft. One rotor employed the rectangular planform metal blades (rotor solidity = 0.089) which were used on the initial flight ...
Alexander, H., Bartie, K., Bishop, H., Lamon, S., Mcveigh, M.   +4 more
core   +1 more source