Results 191 to 200 of about 352,001 (326)

USP10 promotes glioma stem cell maintenance and glioblastoma growth by antagonizing DTX3L-mediated SATB2 ubiquitination. [PDF]

Nat Commun
Guo M, Luo W, Ling P, Lei H, Li L, Duan C, Xue Z, Zhang M, Zhang X, Bao W, Zhou W, Man J, Zhang S, Shu K, Qin J, Wang X, Dong Z, Tao W.   +17 more
europepmc   +1 more source

A Two-Parameter Quasi Lindley Distribution in Acceptance Sampling Plans from Truncated Life Tests

, 2019
Amer Ibrahim Al‐Omari, Amjad D. Al‐Nasser   +1 more
openalex   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

CATSPERε extracellular domains are essential for sperm calcium channel assembly and activity modulation. [PDF]

Sci Adv
Hwang JY, Wang H, Oh JN, Kim J, Finnegan SF, Skakkebaek NE, Chung JJ.   +6 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Improving the value of population health data for health policy and decision-making using machine learning algorithms in EQ-5D-5L index estimation. [PDF]

Sci Rep
Hölgyesi Á, Zrubka Z, Neshat M, Jáger V, Kincses Á, Kovács L, Gulácsi L, Mirjalili S, Péntek M.   +8 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Defective Function of Inhibitor of κB Kinase Subunit Beta Associated With Multiple Immune-Mediated Disorders. [PDF]

Exp Dermatol
Malovitski K, Rosenthal NK, Khair L, Hagin D, Freund T, Sharoni E, Peled A, Feller Y, Ishtewy R, Mohamad J, Sarig O, Samuelov L, Sprecher E, Pavlovsky M.   +13 more
europepmc   +1 more source

Economic Design of Acceptance Sampling Plans for Truncated Life Tests Using Three-Parameter Lindley Distribution

, 2020
Amer Ibrahim Al‐Omari, Enrico Ciavolino, Amjad D. Al‐Nasser   +2 more
openalex   +2 more sources