Results 221 to 230 of about 352,048 (282)

Recurrent mutations in the stress regulator Cap1 reveal a trade-off between azole resistance and oxidative stress response in Candida albicans. [PDF]

PLoS Biol
Zhou X, Hilk A, Solis NV, Scott N, Zajac C, Filler SG, Selmecki A.   +6 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Improving reporting of withdrawal of life-sustaining treatment in acute brain injury trials: a methodologic imperative. [PDF]

Am J Respir Crit Care Med
Taran S, Turgeon AF, Steinberg A, Adhikari NKJ.   +3 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

AtMCM10 facilitates SDSA-mediated intermolecular homologous recombination repair via liquid-liquid phase separation in DNA damage response. [PDF]

Nat Commun
Zhao X, Zhang T, Jin D, Chen H, Xia S, Bai L, Hao X, Huang L, Tian L, Guo Y, Zhao Y, Li D, Gong Z.   +12 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Selective autophagy fine-tunes Stat92E activity by degrading Su(var)2-10/PIAS in <i>Drosophila</i> glia. [PDF]

Life Sci Alliance
Vincze V, Esküdt Z, Fehér-Juhász E, Chhatre AS, Jipa A, Galambos AR, Feil-Börcsök D, Bence M, Juhász G, Szabó Á.   +9 more
europepmc   +1 more source

Fluctuations of end-to-end delays in low-latency WebRTC-based UAV-borne internet of things operating in an urban environment. [PDF]

Sci Rep
Chodorek A, Chodorek RR, Sitek P.
europepmc   +1 more source

Case Report: Deletion in the 5' untranslated region of <i>TAFAZZIN</i> in a boy with Barth syndrome. [PDF]

Front Cardiovasc Med
Singer ES, Smith J, Lin R, Morrish AM, Lal S, Irving C, Casey C, King I, Weintraub RG, Bagnall RD.   +9 more
europepmc   +1 more source