Results 261 to 270 of about 352,001 (326)

Letter to editor: SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis. [PDF]

J Transl Med
Zhao X, Wang X, Wu G, Wu G.
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Profiling truncated variants of TCTN1 unveils the essential role of its integrity for ciliogenesis. [PDF]

iScience
Yu H, Jiang L, Xu C, Li Y, Wang S, Ma Z, Qian Y, Wu Y, Miao C, Dong Z, Wang L.   +10 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Antarctic Microalga Chlamydomonas sp. ICE-L Cryptochrome CiCRY-DASH1 Mediates Efficient DNA Photorepair of UV-Induced Cyclobutane Pyrimidine Dimer and 6-4 Photoproducts. [PDF]

Mar Drugs
Zheng Z, Pan X, Liu Z, Tan Y, Wu Z, Du N.   +5 more
europepmc   +1 more source

Characterization of full-length and cytoplasmic tail-truncated envelope glycoproteins incorporated into human immunodeficiency virus (HIV-1) virions and virus-like particles. [PDF]

J Virol
Anang S, Zhang S, Ennis A, Ding H, Deshpande A, Nguyen HT, Kappes JC, Sodroski JG.   +7 more
europepmc   +1 more source

Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brain. [PDF]

Acta Neuropathol Commun
Shinohara M, Gheni G, Kawai K, Morishima M, Murayama S, Saito Y, Bu G, Sato N.   +7 more
europepmc   +1 more source

Finite element analysis and in vitro simulation experiments on ophthalmic trocar needles. [PDF]

Front Bioeng Biotechnol
Sun J, Zhang Z, Yuan H, Zhao G.
europepmc   +1 more source

Developing the protein quality control system in <i>Streptomyces</i> for selective translation of ultra-long full-length polyketide synthase mRNAs to enhance biosynthesis efficiency. [PDF]

Synth Syst Biotechnol
Jiang C, Hao K, Wang S, Guo R, Li X, Lv L, Luan J, Wang H.   +7 more
europepmc   +1 more source