Results 61 to 70 of about 91,565 (275)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The selective truncated singular value decomposition estimation for ill-posed geophysical observation equations

Applied Mathematics in Science and Engineering
Ill-posed problems are prevalent in geodetic and geophysical data processing, significantly impacting the traditional least squares (LS) estimation.
Xinna Li, Ke Chen, Chaozhong Ma, Shumei Guo, Songhui Han   +4 more
doaj   +1 more source

Adaptive scattered data fitting by extension of local approximations to hierarchical splines

, 2017
We introduce an adaptive scattered data fitting scheme as extension of local least squares approximations to hierarchical spline spaces. To efficiently deal with non-trivial data configurations, the local solutions are described in terms of (variable ...
Bracco, Cesare, Giannelli, Carlotta, Sestini, Alessandra   +2 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Analysis of the Singular Values for Conductivity Reconstruction in Magneto-Acoustic Tomography With Magnetic Induction

IEEE Access, 2020
Due to the acoustic source distribution and limited bandwidth ultrasound measurement, the dominant ultrasound signals always come from the boundary of the electrical conductivity in magneto-acoustic tomography with magnetic induction (MAT-MI).
Ren Ma, Ming Yang, Shunqi Zhang, Xiaoqing Zhou, Tao Yin, Zhipeng Liu   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Numerical Method for Lane-Emden Equations Using Hybrid Functions and the Collocation Method

Journal of Applied Mathematics, 2012
A numerical method to solve Lane-Emden equations as singular initial value problems is presented in this work. This method is based on the replacement of unknown functions through a truncated series of hybrid of block-pulse functions and Chebyshev ...
Changqing Yang, Jianhua Hou
doaj   +1 more source

Medical Image Denoising Based on Biquadratic Polynomial With Minimum Error Constraints and Low-Rank Approximation

IEEE Access, 2020
To improve the visual quality of noisy medical images acquired by low radiation dose imaging, medical image denoising is highly desirable for clinical disease diagnosis.
Linlin Ji, Qiang Guo, Mingli Zhang
doaj   +1 more source

Comparative study on the applicability of regularization method in ship’s magnetic signature modeling based on monopole array

AIP Advances, 2022
In this paper, we first study the applicability and stability of the Tikhonov regularization method (TRM) and the truncated singular value decomposition method in ship’s magnetic signature inversion modeling.
Baowei He, Shengdao Liu, Jingwen Zong
doaj   +1 more source