Results 121 to 130 of about 116,410,484 (294)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Construction Workers Health Trust activity report.
, 2001 The Construction Workers Health Trust was founded following a decision taken at the Construction 2000 Conference in May 1994 by the Construction Group of Unions affiliated to the Irish Congress of Trade Unions, to establish a body dedicated solely to ...
Construction Workers Health Trust
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Verified Trust: Reciprocity, Altruism, and Noise in Trust Games [PDF]
Behavioral economists have come to recognize that reciprocity, the interaction of trust and trustworthiness, is a distinct and economically relevant component of individual preferences alongside selfishness and altruism.
Marius Brülhart, Jean-Claude Usunier
core
Social Platforms in the Deepfake Age: Navigating Media Trust through Media Literacy
JOIV: International Journal on Informatics VisualizationThe issues with social media landscape are proliferation of disinformation, misinformation, and misinformation. The widespread of deepfakes makes is harder to distinguish between authentic content and fabricated content.
Fong Yee Lee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
We introduce trustworthy traders in bilateral trading. Trustworthy traders do not misrepresent their private information. We prove that an increase in the levels of trust (probabilities that traders are trustworthy) can reduce the maximum attainable ...
Saran, Rene
core
, 2016 The issue of trust in our institutions has never been higher in the public agenda. In this path-breaking study, the question of how far the news media are trusted has been posed in a unique way—to ordinary people in focus groups. Their response is that they find the news often incomprehensible and demeaning of their experience.
Coleman, S, Anthony, S, Morrison, D
openaire +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source