Results 191 to 200 of about 185,761 (273)

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla   +16 more
wiley   +1 more source

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

open access: yesAdvanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski   +3 more
wiley   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

Acceptability and feasibility of a mobile electronic medical record system for community-based antiretroviral therapy in Lilongwe, Malawi: A rapid qualitative analysis. [PDF]

open access: yesPLoS One
Kiruthu-Kamamia C   +9 more
europepmc   +1 more source

Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
This study introduces a biphasic granular bioink (µInk) that enables 3D bioprinting of high cell density constructs for dermal regeneration. The bioink promotes cell proliferation, ECM deposition, and neovascularization, leading to tissue integration and reduced scar formation in vivo.
Rozalin Shamasha   +16 more
wiley   +1 more source

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