Molecular Microbiology, Volume 116, Issue 2, Page 564-588, August 2021., 2021 Resistance to diminazene is one of the main problems facing the control of the livestock disease Animal African Trypanosomiasis (AAT, or nagana), caused by the parasite Trypanosoma congolense. We investigated the adaptations of the parasite that allow it to resist the drug and find that changes to the mitochondrion, where the parasite produces its ...
Lauren V. Carruthers +13 more
wiley +1 more source
First case report on the occurrence of Trypanosoma evansi in a Siam B Mare in Kelantan, Malaysia
Veterinary Medicine and Science, Volume 7, Issue 2, Page 303-309, March 2021., 2021 This first positive Surra case in Siam B mare in Kelantan, Malaysia, that is bordering Thailand confirms the increasing concern of transboundary infections. Thin blood smear and examination revealed the presence of Trypanosoma sp., and it was confirmed as T. evansi through molecular identification.
Nur Zul Izzati Mohd Rajdi +6 more
wiley +1 more source
Haematological indices in Trypanosoma brucei brucei (Federe isolate) infected Nigerian donkeys (Equus asinus) treated with homidium and isometamidium chloride of ciprofloxacin in broiler chickens after single intravenous and intraingluvial administration [PDF]
Macedonian Veterinary Review, 2017 The efficacy of intramuscular administration of Homidium chloride (Novidium®) and Isometamidium chloride (Sécuridium®) in Nigerian donkeys (Equus asinus) experimentally infected with T. b. brucei (Federe isolate) was investigated.
Queen Nneka Oparah +4 more
doaj +1 more source
Stress Induces Release of Extracellular Vesicles by Trypanosoma cruzi Trypomastigotes
Journal of Immunology Research, Volume 2021, Issue 1, 2021., 2021 All extracellular forms of Trypanosoma cruzi, the causative agent of Chagas disease, release extracellular vesicles (EVs) containing major surface molecules of the parasite. EV release depends on several mechanisms (internal and external). However, most of the environmental conditions affecting this phenomenon are still unknown.
Camilla Ioshida Vasconcelos +9 more
wiley +1 more source
Veterinary Medicine International, Volume 2021, Issue 1, 2021., 2021 An analytical cross‐sectional study was performed between November 2015 and April 2016 at Hawa Galan woreda, Kelem Wollega Zone, Oromia Region, Ethiopia, to estimate the proportion of cattle with trypanosomosis and to evaluate the elements associated with the prevalence of bovine trypanosomosis.
Girma Tsegaye +3 more
wiley +1 more source
Drug quality analysis of isometamidium chloride hydrochloride and diminazene diaceturate used for the treatment of African animal trypanosomosis in West Africa. [PDF]
BMC Vet Res, 2018 Background Diminazene diaceturate (DA) and isometamidium chloride hydrochloride (ISM) are with homidium bromide, the main molecules used to treat African Animal Trypanosomosis (AAT).
Bengaly Z +11 more
europepmc +2 more sources
Trypanocidal Activity of Flavanone Derivatives [PDF]
Molecules, 2020 Chagas disease, also known as American trypanosomiasis, is classified as a neglected disease by the World Health Organization. For clinical treatment, only two drugs have been on the market, Benznidazole and Nifurtimox, both of which are recommended for use in the acute phase but present low cure rates in the chronic phase.
Gabriela Maciel Diogo +5 more
openaire +3 more sources
Trypanocide Use and Molecular Characterization of Trypanosomes Resistant to Diminazene Aceturate in Cattle in Northern Côte D'Ivoire. [PDF]
Trop Med Infect DisThe resistance of trypanosomes to the doses of trypanocide administered by farmers to their animals acts as a real brake on efforts to control to combat African trypanosomiasis.
Ekra JY +6 more
europepmc +2 more sources
Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from Polygonum salicifolium. [PDF]
Pathogens, 2021 Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by several species of parasites belonging to the family Trypansomatida. The present study investigated the antitrypanosomal and antileishmanial activity of chalcones and
Zheoat AM +9 more
europepmc +2 more sources
Synthesis and Evaluation of Trypanocidal Activity of Chromane-Type Compounds and Acetophenones
Molecules, 2021 American trypanosomiasis (Chagas disease) caused by the Trypanosoma cruzi parasite, is a severe health problem in different regions of Latin America and is currently reported to be spreading to Europe, North America, Japan, and Australia, due to the ...
Luis A. González +4 more
doaj +1 more source