Results 61 to 70 of about 2,686 (230)

Trypanocidal Activity of Aziridinyl Nitrobenzamide Prodrugs [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT The trypanocidal agents nifurtimox and benznidazole both function as prodrugs and must undergo enzyme-mediated activation, a reaction catalyzed by type I nitroreductase (NTR). In the search for new parasitic therapies, we have utilized this finding to investigate whether aziridinyl nitrobenzamide derivatives have ...
Bot, C, Hall, BS, Bashir, N, Taylor, MC, Helsby, NA, Wilkinson, SR   +5 more
openaire   +3 more sources

Impact of long‐term mass‐rearing on the genetic structure of tsetse fly Glossina palpalis gambiensis colonies

Insect Science, Volume 32, Issue 5, Page 1575-1587, October 2025.
Abstract Tsetse flies are the sole cyclic vectors of African trypanosomes, which cause human and animal African trypanosomiases in Africa. Tsetse fly control remains a promising option for disease management. The sterile insect technique (SIT) stands as an environmentally friendly tool to control tsetse populations.
Kiswend‐sida M. Dera, Soumaïla Pagabeleguem, Tito Tresor Melachio Tanekou, Ange Irénée Toé, Gisèle Marie Sophie Ouedraogo‐Sanou, Adrien Marie Gaston Belem, Sophie Ravel, Robert L. Mach, Marc J. B. Vreysen, Adly M.M. Abd‐Alla   +9 more
wiley   +1 more source

Mise en évidence d'une résistance aux trypanocides parmi des souches de Trypanosoma congolense récemment isolées au Burkina

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1984
Dix-huit souches de T. congolense ont fait l'objet d'une épreuve de sensibilité à l'acétate de diminazène et à l'isométamidium chez la souris. L'intérêt et les limites de cette épreuve sont discutés. Les 13 souches de T.
Edith Authié
doaj   +1 more source

Evaluation of two candidate molecules—TCTP and cecropin—on the establishment of Trypanosoma brucei gambiense into the gut of Glossina palpalis gambiensis

Insect Science, Volume 32, Issue 5, Page 1747-1760, October 2025.
This study investigates the potential of enhancing the resistance of Glossina palpalis gambiensis to Trypanosoma brucei gambiense to mitigate the transmission of Human African Trypanosomiasis. We successfully cloned genes encoding proteins of interest in Sodalis strains, resulting in recombinant Sodalis (recSodalis) that were micro‐injected into the L3
François Sougal Ngambia Freitas, Linda De Vooght, Flobert Njiokou, Jan Van Den Abeele, Géraldine Bossard, Bernadette Tchicaya, Rosa Milagros Corrales, Sophie Ravel, Anne Geiger, David Berthier‐Teyssedre   +9 more
wiley   +1 more source

Elimination des glossines et trypanosomoses animale : Résultats de quelques sondages dans la région du lac Tchad

Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1978
Les enquêtes par sondages effectuées dans la vallée du Bas-Chari au Tchad pour juger de l'incidence de la disparition des glossines et des traitements trypanocides de masse sur l'épidémiologie des trypanosomoses locales (T. vivax et T. evansi) ont montré
Yves Tazé, J. Gruvel
doaj   +1 more source

Insights into Ergosterol Peroxide’s Trypanocidal Activity [PDF]

Biomolecules, 2019
Trypanosoma cruzi, which causes Chagas disease, is a significant health threat in many countries and affects millions of people. Given the magnitude of this disease, a broader understanding of trypanocidal mechanisms is needed to prevent and treat infection.
Thuluz Meza-Menchaca, Angel Ramos-Ligonio, Aracely López-Monteon, Abraham Vidal Limón, Leonid Kaluzhskiy, Tatjana V. Shkel, Natallia V. Strushkevich, Luis Jiménez-García, Lourdes Agredano Moreno, Verónica Gallegos-García, Jorge Suárez-Medellín, Ángel Trigos   +11 more
openaire   +3 more sources

Spatiotemporal changes in prevalence of Sodalis glossinidius, Spiroplasma spp. and trypanosome species in wild Glossina tachinoides from Sora‐Mboum animal African trypanosomiasis focus in northern Cameroon

Insect Science, Volume 32, Issue 5, Page 1713-1725, October 2025.
Abstract Sterile Insect Technique (SIT) has proven effective to reduce tsetse population density in large infected areas where animal African trypanosomosis (AAT) and human African trypanosomiasis (HAT) elimination was difficult to achieve. However, the decrease in mass production of insectary‐reared tsetse and the limited but incomplete knowledge on ...
Steve Feudjio Soffack, Tito T. Melachio Tanekou, Hugues C. Nana Djeunga, Oumarou Farikou, Ginette I. Kame Ngasse, Mureille C. Tchami Mbagnia, Murielle Wondji, Charles S. Wondji, Hager Khalil, Adly M. M. Abd‐Alla, Anne Geiger, Gustave Simo, Flobert Njiokou   +12 more
wiley   +1 more source

Immune Response in Cattle Trypanosomosis and Trypanotolerance: Main Findings and Gaps

Parasite Immunology, Volume 46, Issue 11, November 2024.
ABSTRACT Trypanosome parasites of the genus Trypanosoma cause African animal trypanosomosis, a devastating livestock disease plaguing sub‐Saharan Africa. Unlike many protozoan parasites, these extracellular blood‐borne pathogens directly engage the host's immune system. While the mouse model has provided valuable insights, a comprehensive understanding
Gnohion Fabrice Somé, Modou Séré, Bienvenu Martin Somda, Guiguigbaza‐Kossigan Dayo, Georges Anicet Ouédraogo, Alain Boulangé, Ghizlane Maarifi, Isabelle Chantal, David Berthier‐Teyssedre, Sophie Thévenon   +9 more
wiley   +1 more source

A 3D-QSAR Study on the Antitrypanosomal and Cytotoxic Activities of Steroid Alkaloids by Comparative Molecular Field Analysis

Molecules, 2018
As part of our research for new leads against human African trypanosomiasis (HAT), we report on a 3D-QSAR study for antitrypanosomal activity and cytotoxicity of aminosteroid-type alkaloids recently isolated from the African medicinal plant Holarrhena ...
Charles Okeke Nnadi, Julia Barbara Althaus, Ngozi Justina Nwodo, Thomas Jürgen Schmidt   +3 more
doaj   +1 more source

Effets sur Glossina palpalis gambiensis de substances médicamenteuses administrées au lapin hôte-nourricier. Deuxième partie [PDF]

, 1979
Les auteurs étudient les effets, chez des femelles de Glossina palpalis gambiensis, d'un seul repas sanguin pris sur un animal nourricier (lapin) auquel a été administré un produit pharmaceutique à dose thérapeutique. Plusieurs produits ont été testés: 2
Bourdoiseau, G., Cuisance, Dominique, Février, Jacques, Politzar, H., Sellin, E.   +4 more
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