Results 71 to 80 of about 2,686 (230)
ChemMedChem, Volume 19, Issue 9, May 2, 2024.Several (sub)species of Trypanosoma are responsible for human African trypanosomiasis (HAT), Chagas disease, and Nagana. These (sub)species have different drug susceptibility profiles. This work reports several easily accessed quinolone hydrazides exhibiting sub‐micromolar activities against multiple (sub)species of Trypanosoma.
Kgothatso A. Chirwa +7 more
wiley +1 more source
Onderstepoort Journal of Veterinary Research, 2019 African animal trypanosomosis (AAT) is caused by several species of the genus Trypanosoma, a parasitic protozoan infecting domestic and wild animals. One of the major effects of infection with pathogenic trypanosome is anaemia.
Abdalla A. Latif +2 more
doaj +1 more source
Cinétique de la mort in vitro de Trypanosoma vivax et Trypanosoma congolense Vanderplank au contact de médicaments trypanocides [PDF]
, 1967 Trypanosoma vivax et Trypanosoma congolense ont été soumis in vitro à l'action de trypanocides appartenant à trois familles chimiques: diamidine, quinoléine et phénanthridine.
Touré, Saydil
core
DFMO inhibition of neuroblastoma tumorigenesis
Cancer Medicine, Volume 13, Issue 9, May 2024.Abstract Background Most high‐risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event‐free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during maintenance therapy.
Divya Gandra +8 more
wiley +1 more source
Insecticide and Repellent Mixture Pour-On Protects Cattle against Animal Trypanosomosis.
PLoS Neglected Tropical Diseases, 2016 BackgroundAfrican animal trypanosomosis (AAT), transmitted by tsetse flies and tick-borne diseases are the main constraints to livestock production in sub-Saharan Africa.
Geoffrey Gimonneau +6 more
doaj +1 more source
Revisiting zoonotic human African trypanosomiasis control in Uganda
, 2015 Objectives: Human migration and concomitant HIV infections are likely to bring about major changes in the epidemiology of zoonotic parasitic infections. Human African trypanosomiasis (HAT) control is particularly fraught with intricacies.
Menon, Sonia +3 more
core +1 more source
Bisguanidine, Bis(2-aminoimidazoline), and Polyamine Derivatives as Potent and Selective Chemotherapeutic Agents against Trypanosoma brucei rhodesiense. Synthesis and in Vitro Evaluation [PDF]
, 2013 The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of an in-house library of 62 compounds [i.e. alkane, diphenyl, and azaalkane bisguanidines and bis-(2-aminoimidazolines)], which were chosen for their structural ...
Brun, Reto, Dardonville, Christophe
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The script supports Chapter 5 subsection 2 titled: “Trypanocide advancements and challenges in Uganda” from my PhD thesis titled: Exploring trypanocide resistance: Lessons from Uganda (2024). This describes data (referenced as “trypCounterfeit”) were the quality of trypanocides i.e., diminazene aceturate (DA), isometamidium chloride (ISM) and homidium ...
Kasozi, Keneth Iceland +2 more
openaire +2 more sources
Evaluating 5-Nitrothiazoles as Trypanocidal Agents [PDF]
Antimicrobial Agents and Chemotherapy, 2016 ABSTRACTThe growth-inhibitory properties of a 5-nitrothiazole series were evaluated againstTrypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the ...
O'Shea, IP +3 more
openaire +3 more sources
Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024.Abstract Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa. Drugs used for treatment against HAT first stage have limited effectiveness, and the second stage drugs have ...
Anna Seetsi +5 more
wiley +1 more source