Results 81 to 90 of about 2,686 (230)
Prothidium and isometamidium as drug against Trypanosoma brucei canine trypanosomiasis [PDF]
, 1970 Le Prothidium et l'Isométamidium ont été utilisés dans le traitement de plusieurs cas de trypanosomiase expérimentale du chien à Trypanosoma brucei. Le Prothidium est administré à raison de 2 mg/kg de la solution à 2 p.100 et l'Isométamidium 1 mg/kg de ...
Touré, Saydil
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Evaluating 5-Nitrofurans as Trypanocidal Agents [PDF]
Antimicrobial Agents and Chemotherapy, 2013 ABSTRACTThe nitroheterocycle nifurtimox, as part of a nifurtimox-eflornithine combination therapy, represents one of a limited number of treatments targetingTrypanosoma brucei, the causative agent of human African trypanosomiasis. The mode of action of this prodrug involves an initial activation reaction catalyzed by a type I nitroreductase (NTR), an ...
Bot, C +6 more
openaire +3 more sources
Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. [PDF]
PLoS Neglected Tropical Diseases, 2009 BACKGROUND: Human African trypanosomiasis (HAT), a major parasitic disease spread in Africa, urgently needs novel targets and new efficacious chemotherapeutic agents.
Sabine Kuettel +6 more
doaj +1 more source
Revue Malienne d’Infectiologie et de Microbiologie, 2016 La glossine, vecteur majeur de transmission des trypanosomoses animales et humaines est une contrainte pour le développement de l’agriculture et de l’élevage au Mali.
BASS B +6 more
doaj +3 more sources
Trypanocidal Activity of Marine Natural Products [PDF]
Marine Drugs, 2013 Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, human African trypanosomiasis and Chagas disease, for which very few drugs are currently available.
Amy Jones +3 more
openaire +4 more sources
Simultaneous estimation of risk and time preferences among small-scale cattle farmers in West Africa [PDF]
, 2012 This study investigates risk and time preferences of small-holder cattle farmers in West Africa. We apply a discounted utility model and jointly estimate a prospect theory-based utility function and a quasi-hyperbolic discounting function using a maximum
Liebenehm, Sabine, Waibel, Hermann
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BMC Research Notes, 2019 Objective In Sub-Saharan Africa, there is an increase in trypanosome non-susceptibility to multiple trypanocides, but limited information on judicious trypanocide use is accessible to smallholder farmers and agricultural stakeholders in disease endemic ...
Sarah A. O. Wamwenje +5 more
doaj +1 more source
Trypanocidal Activity of Melamine-Based Nitroheterocycles [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT A series of nitroheterocyclic compounds were designed with linkages to melamine or benzamidine groups that are known substrates of the P2 aminopurine and other transporters in African trypanosomes of the brucei group.
Mhairi L, Stewart +7 more
openaire +2 more sources
Prothidium and isometamidium as drug against Trypanosoma brucei canine trypanosomiasis
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1970 Le Prothidium et l'Isométamidium ont été utilisés dans le traitement de plusieurs cas de trypanosomiase expérimentale du chien à Trypanosoma brucei. Le Prothidium est administré à raison de 2 mg/kg de la solution à 2 p.100 et l'Isométamidium 1 mg/kg de ...
Saydil Touré
doaj +1 more source
Immunopathological aspects of trypanosomal meningoencephalitis in vervet monkeys after relapse following BerenilR treatment [PDF]
, 2017 Four quarantined vervet monkeys were treated with intramuscular BerenilR in patent CNS infection after experimental trypanosome inoculation with Trypanosoma brucei rhodesiense or T. brucei brucei.
Bovell, D. +4 more
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