Synthesis of Quinic Acid‐Derived Sialylmimetics and Their Effects on T. cruzi and Trans‐Sialidase
ChemistrySelect, Volume 10, Issue 16, April 25, 2025.The synthesis of sialylmimetic hybrids using quinic and shikimic acids as precursors was achieved in a single synthetic route to produce two isomers (5S‐ and 5R), incorporating the 4‐(4‐nitrophenyl)‐1H‐1,2,3‐triazole units, as novel leads for Chagas disease treatment.
Dayan Setton Amancio +7 more
wiley +1 more source
Action of Trypanosoma rangeli in infections with virulent Trypanosoma cruzi populations
Memorias do Instituto Oswaldo Cruz, 2003 In experimental murine infections with Trypanosoma rangeli it has been observed development immune response to Trypanosoma cruzi. The aim of the present work was to analyze the result of antigenic stimuli and the protective effect with T.
MT Paláu +3 more
doaj +1 more source
Dynamics of Immobilized Flagella [PDF]
arXiv, 2003 Although the auger-like 'swimming' motility of the African trypanosome was described upon its discovery over one hundred years ago, the precise biomechanical and biophysical properties of trypanosome flagellar motion has not been elucidated. In this study, we describe five different modes of flagellar beat/wave patterns in African trypanosomes by ...
arxiv
Chagas disease reactivation in a heart transplant patient infected by domestic Trypanosoma cruzi discrete typing unit I (TcIDOM) [PDF]
, 2015 Background Trypanosoma cruzi, causative agent of Chagas disease, displays high intraspecific genetic diversity: six genetic lineages or discrete typing units (DTUs) are currently recognized, termed TcI through TcVI.
Bhattacharyya, T. +7 more
core +2 more sources
Observaciones sobre trypanosomas en Colombia
Revista de la Facultad de Medicina, 1941 I Observaciones sobre trypanosoma cruzi II Observaciones sobre trypanosoma rangeli III Anotaciones sobre un trypanosoma del Dassyprocta ...
Hernando Rey Matiz
doaj
Contribuição ao estudo da infecção de morcegos por hemoflagelados do gênero Trypanosoma Gruby, 1843
Cadernos de Saúde Pública, 1991 O presente estudo foi realizado no período de julho de 1983 a dezembro de 1984, nos municípios cearenses de Russas, Palhano, Limoeiro do Norte, Morada Nova, Canindé, Quixadá e Pereiro, os quais correspondem a parte da área endêmica da tripanossomíase ...
Marta E. Fabián
doaj +1 more source
A Computational Approach to Extinction Events in Chemical Reaction Networks with Discrete State Spaces [PDF]
arXiv, 2017 Recent work of M.D. Johnston et al. has produced sufficient conditions on the structure of a chemical reaction network which guarantee that the corresponding discrete state space system exhibits an extinction event. The conditions consist of a series of systems of equalities and inequalities on the edges of a modified reaction network called a ...
arxiv
Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]
, 2017 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel +5 more
core +3 more sources
BMC Genomics, 2015 Due to the absence of transcription initiation regulation of protein coding genes transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the majority of gene expression changes in trypanosomatids.
P. Smircich +10 more
semanticscholar +1 more source
Immunity and immune modulation in Trypanosoma cruzi infection.
Pathogens and Disease, 2015 Chagas disease is caused by the protozoan Trypanosoma cruzi. The parasite reaches the secondary lymphoid organs, the heart, skeletal muscles, neurons in the intestine and esophagus among other tissues.
F. Cardillo +3 more
semanticscholar +1 more source